MSH4 Inhibitors
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine inhibits MSH4 by binding to DNA and interfering with the homologous recombination repair process, directly impacting the ability of MSH4 to mediate the repair of double-strand breaks. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Ellagic acid inhibits MSH4 function by binding to DNA at sites critical for the initiation of repair processes, thereby preventing MSH4 from effectively participating in the repair of DNA mismatches. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
This compound inhibits MSH4 by altering the redox state within the cell, which affects the enzymatic activity of DNA repair proteins, including MSH4, thereby impairing their ability to correct DNA mismatches. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin inhibits MSH4 by forming DNA cross-links that are not easily repaired, effectively overwhelming the repair capacity of MSH4 and leading to the accumulation of unrepaired DNA damage. | ||||||
Carboplatin | 41575-94-4 | sc-202093 sc-202093A | 25 mg 100 mg | $48.00 $135.00 | 14 | |
Carboplatin forms DNA adducts that inhibit MSH4 by preventing the proper binding and repair of mismatched DNA, leading to an increase in genomic instability. | ||||||
Oxaliplatin | 61825-94-3 | sc-202270 sc-202270A | 5 mg 25 mg | $112.00 $394.00 | 8 | |
Oxaliplatin inhibits MSH4 by creating platinum-DNA adducts, which MSH4 cannot efficiently repair, thus hindering the normal DNA repair process and promoting the accumulation of DNA errors. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate indirectly inhibits MSH4 by reducing the availability of nucleotides necessary for DNA repair, thereby impairing the ability of MSH4 to mediate the repair of mismatches during DNA synthesis. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Fluorouracil inhibits MSH4 by being incorporated into DNA in place of uracil, creating mismatches that MSH4 is unable to correct, thereby interfering with DNA synthesis and function. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
Olaparib inhibits MSH4 by targeting PARP enzymes involved in the DNA damage response, reducing the efficiency of MSH4-mediated repair and leading to the accumulation of DNA damage. | ||||||
Rucaparib | 283173-50-2 | sc-507419 | 5 mg | $150.00 | ||
Rucaparib inhibits MSH4 by a mechanism similar to Olaparib, specifically by inhibiting PARP enzymes and thereby decreasing the repair capacity of MSH4 in response to DNA damage. | ||||||