MS4A6D Activators
MS4A6D (Membrane-spanning 4-domains subfamily A6D) is a protein that belongs to a larger family of MS4A proteins, which are known to be involved in diverse cellular processes due to their membrane-associated nature. Activators of MS4A6D would, therefore, be a class of compounds that can enhance the normal function or activity of this protein. The search for MS4A6D activators would likely commence with the development of a specific assay capable of detecting changes in the function of MS4A6D. Such an assay might involve monitoring the protein's ability to facilitate cellular processes or its interaction with other cellular components. For example, if MS4A6D were known to participate in ion transport, the assay might measure the ionic currents across a membrane. High-throughput screening (HTS) could then be utilized to examine a vast library of small molecules to identify those that cause an increase in the measured activity, suggesting that they act as activators of MS4A6D.
Following the identification of promising compounds through HTS, further experiments would be necessary to confirm and understand the activation mechanism. Secondary validation assays would be designed to confirm the specificity of the interaction between the activator and MS4A6D. Techniques such as isothermal titration calorimetry (ITC) could be employed to measure the thermodynamics of the activator binding to MS4A6D, while surface plasmon resonance (SPR) might be used to gather kinetic data on the binding process. These detailed studies can reveal whether the binding of the activator to MS4A6D is direct and can provide insights into the strength and duration of the interaction. Furthermore, structural studies, including X-ray crystallography or cryo-electron microscopy (cryo-EM), could be undertaken to visualize the molecular details of the interaction between MS4A6D and the activator.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an adenylate cyclase activator, which increases the levels of cyclic AMP (cAMP) within the cell. Elevated cAMP levels can lead to the activation of protein kinase A (PKA), which may indirectly enhance the activity of MS4A6D in cellular signaling. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective phosphodiesterase inhibitor that prevents the breakdown of cAMP and cGMP, thereby sustaining their signaling activity. This can lead to enhanced PKA activity and could indirectly promote MS4A6D activity through cAMP-dependent pathways. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Br-cAMP is a cell-permeable cAMP analog that activates PKA. By mimicking cAMP and directly activating PKA, it can indirectly support the activation of MS4A6D by amplifying cAMP-dependent signaling pathways. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calcium-dependent signaling pathways, potentially leading to the indirect enhancement of MS4A6D activity involved in calcium-regulated processes. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore that raises intracellular calcium levels. Like Ionomycin, it can indirectly enhance MS4A6D activity by activating calcium-dependent signaling pathways where MS4A6D may be involved. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) is a diacylglycerol (DAG) analog that activates protein kinase C (PKC). PKC activation can modulate various signaling pathways and may indirectly enhance the activity of MS4A6D within those pathways. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate is a bioactive lipid that activates sphingosine-1-phosphate receptors, triggering signaling pathways that may involve MS4A6D. This can lead to indirect enhancement of MS4A6D activity in processes such as immune cell signaling. | ||||||
BAY 60-6583 | 910487-58-0 | sc-503262 | 10 mg | $210.00 | ||
BAY 60-6583 is a selective adenosine A2B receptor agonist. Activation of this receptor leads to increased cAMP levels, which can indirectly enhance MS4A6D activity through cAMP-dependent signaling pathways. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4) which degrades cAMP. Inhibition of PDE4 leads to increased cAMP levels, potentially enhancing MS4A6D activity indirectly by promoting cAMP-dependent signaling pathways. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can activate stress-activated protein kinases (SAPKs), such as JNK. Activation of SAPKs can lead to indirect enhancement of MS4A6D in cellular stress response pathways. | ||||||