MS4A6D Inhibitors
Chemical inhibitors of MS4A6D function by interacting with various signaling pathways and enzymes that are crucial for the protein's activity. Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which is known to phosphorylate proteins including MS4A6D, resulting in its inhibition. Similarly, several PKC inhibitors such as Staurosporine, Chelerythrine Chloride, Bisindolylmaleimide I (also known as GF109203X), and Go 6983, operate by preventing the phosphorylation process essential for MS4A6D's activity. By halting phosphorylation, these inhibitors disrupt the functional expression of MS4A6D. Genistein, as a tyrosine kinase inhibitor, can inhibit MS4A6D by blocking the phosphorylation of tyrosine residues on proteins that may be associated with MS4A6D's signaling mechanisms.
In addition to these, LY294002 functions by inhibiting PI3K, which is an upstream regulator in many signaling pathways, including those associated with MS4A6D. The disruption of the PI3K/Akt pathway by LY294002 can lead to the inhibition of MS4A6D by affecting downstream signaling events. Rapamycin operates through the inhibition of the mTOR pathway, which is another significant pathway that can affect the functional expression and activity of MS4A6D. W-7 Hydrochloride acts as a calmodulin antagonist and can inhibit MS4A6D by interfering with calcium signaling, which is vital for numerous cellular processes, including those involving MS4A6D. U73122 inhibits phospholipase C, which is pivotal in various intracellular signaling cascades, thereby inhibiting MS4A6D by altering the signaling environment it requires. Lastly, PD98059 inhibits the MEK/ERK pathway, which plays a part in the regulation and activity of MS4A6D, leading to its inhibition upon the disruption of this pathway.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) inhibits MS4A6D by activating protein kinase C (PKC), which in turn can phosphorylate substrates that may include MS4A6D or proteins closely associated with it, leading to a functional inhibition of MS4A6D's activity. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent PKC inhibitor that can indirectly inhibit MS4A6D by preventing the phosphorylation of proteins in the PKC pathway that are essential for MS4A6D's function. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can inhibit MS4A6D by blocking the phosphorylation of tyrosine residues on proteins within its pathway, potentially including MS4A6D itself or proteins that interact with it, leading to decreased functionality. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $90.00 $317.00 | 17 | |
Chelerythrine is a selective PKC inhibitor that can inhibit MS4A6D by preventing the PKC-mediated phosphorylation of proteins that could be critical for the functional expression of MS4A6D. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I acts as a PKC inhibitor, which can inhibit MS4A6D by blocking the phosphorylation events necessary for MS4A6D's activity, assuming that PKC is upstream of MS4A6D. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that can indirectly inhibit MS4A6D by disrupting the PI3K/Akt pathway, potentially affecting downstream proteins that interact with or regulate MS4A6D, leading to its functional inhibition. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which can lead to the functional inhibition of MS4A6D by affecting downstream signaling events that are necessary for the full functional expression and activity of MS4A6D. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $166.00 $306.00 $1675.00 | 18 | |
W-7 Hydrochloride is a calmodulin antagonist that can inhibit MS4A6D by interfering with calcium signaling pathways, which could be integral to MS4A6D's function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a MEK inhibitor that can inhibit MS4A6D by blocking the MEK/ERK pathway, potentially affecting proteins that are part of the signaling cascade where MS4A6D is functionally involved. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Go 6983 is a PKC inhibitor, which can inhibit MS4A6D by preventing phosphorylation of proteins within the PKC pathway that MS4A6D may be functionally associated with or dependent upon. | ||||||