MRP1 Activators
Common MRP1 Activators include, but are not limited to Cisplatin CAS 15663-27-1, Doxorubicin CAS 23214-92-8, Vinblastine CAS 865-21-4, Curcumin CAS 458-37-7 and cis-Resveratrol CAS 61434-67-1.
Chemical class of MRP1 Activators are compounds that have the capability to stimulate the activity of the multidrug resistance-associated protein 1 (MRP1), also known as ABCC1. MRP1 is a member of the ATP-binding cassette (ABC) transporter superfamily, and it functions as an efflux pump located in the plasma membrane of various cells, including cancer cells. MRP1 plays a pivotal role in cellular detoxification by actively transporting a wide range of substrates, including drugs, toxins, and endogenous compounds, out of cells. This efflux activity contributes to cellular defense mechanisms against harmful substances and contributes to drug resistance in cancer cells.
Studying MRP1 activators is of great interest in the field of pharmacology and cell biology, as they provide valuable tools to investigate the intricate regulatory mechanisms that control drug efflux and cellular detoxification. By modulating MRP1 activity, researchers can better understand how this transporter contributes to drug resistance in cancer cells and how it affects the pharmacokinetics of various compounds. Furthermore, understanding the structure-activity relationship of MRP1 activators can help design compounds that enhance the activity of this transporter selectively, leading to improved strategies for research. In summary, the exploration of MRP1 Activators as a chemical class contributes to advancing our understanding of cellular defense mechanisms.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Platinum-based compound used for cancers. Upregulates MRP1 to eliminate cellular toxins. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Induces MRP1 expression to reduce suggested compound accumulation. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Triggers MRP1 expression to facilitate suggested compound efflux. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Polyphenol found in grapes and berries with suggested potential health benefits. Induces MRP1 to aid suggested compound elimination. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Topoisomerase inhibitor may increase MRP1 expression to promote suggested compound efflux. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $256.00 | 18 | |
Selective estrogen receptor modulator may Induce MRP1 to assist in suggested compound resistance. | ||||||
Carboplatin | 41575-94-4 | sc-202093 sc-202093A | 25 mg 100 mg | $47.00 $132.00 | 14 | |
Platinum-based compound similar to cisplatin. Upregulates MRP1 to reduce suggested compound cytotoxicity. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $57.00 $93.00 $240.00 $713.00 | 8 | |
Polyphenol found in various fruits and nuts. Induces MRP1 expression for cellular detoxification. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Chemical used in plastics and resins. Upregulates MRP1 to aid in detoxification of xenobiotics. | ||||||