Date published: 2026-5-30

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MRP-S36 Inhibitors

The inhibitors of MRP-S36 are a diverse set of chemical compounds that exert their inhibitory effects by targeting various components of the mitochondrial protein synthesis machinery and related cellular energy production processes. These inhibitors include compounds that bind to ribosomes-akin to the evolutionary similarity between mitochondrial and bacterial ribosomes-which prevents the proper assembly and function of the mitochondrial ribosome, thereby indirectly impeding the function of MRP-S36. Other compounds in this class target the mitochondrial DNA replication process, leading to chain termination and potential disruptions in mitochondrial protein synthesis, which is essential for the normal function of MRP-S36 as part of the mitochondrial ribosome. Some inhibitors operate by obstructing the electron transport chain, a critical component of the mitochondrial energy production pathway, thereby indirectly affecting the energy-dependent processes essential for MRP-S36's activities within the mitochondrion. Furthermore, certain inhibitors interact with the ATP synthesis process by binding to ATP synthase, which is vital for maintaining the high levels of ATP required for the proper function of mitochondrial ribosomal proteins including MRP-S36. Inhibition of ATP synthesis results in a decrease of ATP availability, a critical energy source for the assembly and function of the mitochondrial ribosome, thus indirectly leading to reduced functional activity of MRP-S36. There are also inhibitors that target peptide deformylase, an enzyme involved in protein maturation within mitochondria; hindrance of this enzyme can lead to improper protein synthesis, which again indirectly affects the role of MRP-S36 in the ribosome.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Oligomycin A

579-13-5sc-201551
sc-201551A
sc-201551B
sc-201551C
sc-201551D
5 mg
25 mg
100 mg
500 mg
1 g
$179.00
$612.00
$1203.00
$5202.00
$9364.00
26
(1)

Targets ATP synthase in mitochondria, thereby impeding ATP production. MRP-S36, being part of the mitochondrial ribosome, requires ATP for proper assembly and function, hence inhibition of ATP synthesis indirectly hampers MRP-S36 activity.

Chloramphenicol

56-75-7sc-3594
25 g
$90.00
10
(1)

Binds to bacterial ribosomes and inhibits protein synthesis. Since MRP-S36 is a mitochondrial ribosomal protein, chloramphenicol can interfere with its function by analogy to bacterial ribosomes due to the evolutionary similarity of mitochondria to bacteria.

Erythromycin

114-07-8sc-204742
sc-204742A
sc-204742B
sc-204742C
5 g
25 g
100 g
1 kg
$57.00
$245.00
$831.00
$1331.00
4
(3)

Binds to ribosomes and inhibits protein synthesis, potentially affecting MRP-S36 function due to the similarities between mitochondrial and bacterial ribosomes.

3′-Azido-3′-deoxythymidine

30516-87-1sc-203319
10 mg
$61.00
2
(1)

A nucleoside reverse transcriptase inhibitor that can incorporate into the mitochondrial DNA, leading to termination of the DNA chain and potential disruptions in mitochondrial protein synthesis, indirectly affecting MRP-S36.

Tetracycline

60-54-8sc-205858
sc-205858A
sc-205858B
sc-205858C
sc-205858D
10 g
25 g
100 g
500 g
1 kg
$63.00
$94.00
$270.00
$417.00
$634.00
6
(1)

Interacts with the 30S subunit of bacterial ribosomes, inhibiting protein synthesis. This action can impair MRP-S36 function due to the resemblance of mitochondrial ribosomes to bacterial ribosomes.

Actinonin

13434-13-4sc-201289
sc-201289B
5 mg
10 mg
$170.00
$385.00
3
(1)

A peptide deformylase inhibitor that could impede mitochondrial protein maturation, as peptide deformylase is necessary for N-terminal methionine removal in nascent proteins, this could indirectly affect MRP-S36.

Doxycycline-d6

564-25-0 unlabeledsc-218274
1 mg
$16500.00
(0)

Binds to the 30S subunit of bacterial ribosomes, which could analogously affect the mitochondrial ribosomes and thus the function of MRP-S36.

Puromycin

53-79-2sc-205821
sc-205821A
10 mg
25 mg
$166.00
$322.00
436
(1)

Causes premature chain termination during protein synthesis by acting on ribosomes. This could indirectly hinder MRP-S36 activity if it affects mitochondrial ribosomes in a manner similar to bacterial ribosomes.

Antimycin A

1397-94-0sc-202467
sc-202467A
sc-202467B
sc-202467C
5 mg
10 mg
1 g
3 g
$55.00
$63.00
$1675.00
$4692.00
51
(1)

Inhibits the electron transport chain by binding to cytochrome c reductase, potentially leading to inadequate energy supply for the proper functioning of mitochondrial proteins including MRP-S36.