Date published: 2026-5-15

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MRP-S18C Inhibitors

MRP-S18C Inhibitors belong to a distinct chemical class characterized by their ability to modulate the activity of the MRP-S18C protein. The MRP-S18C protein, also known as Multidrug Resistance-associated Protein S18C, is a member of the ATP-binding cassette (ABC) transporter superfamily. ABC transporters play a crucial role in cellular detoxification and the efflux of various substrates across biological membranes. The MRP-S18C variant, in particular contributing to the efflux of diverse compounds from cells. MRP-S18C Inhibitors act by selectively interfering with the function of this transporter, thereby modulating the cellular disposition of substrates that would normally be expelled by MRP-S18C. The chemical structures of MRP-S18C Inhibitors are diverse, reflecting the broad range of compounds that can effectively interact with the MRP-S18C protein. Researchers have focused on elucidating the molecular mechanisms underlying the inhibitory effects of these compounds, aiming to develop a deeper understanding of how MRP-S18C Inhibitors. The intricate interplay between the chemical features of these inhibitors and the specific binding sites on the MRP-S18C protein remains an area of active investigation. By unraveling the complexities of MRP-S18C Inhibitors laying the foundation for potential future applications in various fields.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

An mTOR inhibitor that can lead to the suppression of the translation of specific proteins including MRP-S18C by inhibiting mTORC1, which would otherwise facilitate protein translation.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

A PI3K inhibitor that reduces AKT phosphorylation, ultimately leading to decreased mTOR activity which is necessary for the translation of certain proteins, including MRP-S18C.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$40.00
$92.00
212
(2)

An MEK inhibitor that prevents the activation of the ERK pathway, potentially reducing the translation of proteins like MRP-S18C that are downstream of this signaling cascade.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$64.00
$246.00
136
(2)

An inhibitor of MEK1/2, which blocks the MAPK/ERK pathway, leading to reduced activity of transcription factors that could potentially control the expression of proteins like MRP-S18C.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$67.00
$223.00
$425.00
97
(3)

A potent PI3K inhibitor that impedes AKT signaling, which may indirectly result in lesser synthesis of certain proteins, possibly including MRP-S18C through mTOR pathway inhibition.

Triciribine

35943-35-2sc-200661
sc-200661A
1 mg
5 mg
$104.00
$141.00
14
(1)

An AKT inhibitor that can decrease the phosphorylation and activity of mTOR, thereby potentially downregulating the translation of proteins like MRP-S18C.

Torin 1

1222998-36-8sc-396760
10 mg
$245.00
7
(1)

An mTORC1/mTORC2 inhibitor that can disrupt protein translation by inhibiting the activities of mTOR complexes, which could lead to decreased levels of MRP-S18C.

Everolimus

159351-69-6sc-218452
sc-218452A
5 mg
50 mg
$131.00
$651.00
7
(1)

An mTOR inhibitor, similar to rapamycin, that can suppress the synthesis of proteins such as MRP-S18C by inhibiting mTORC1-dependent signaling.

Spautin-1

1262888-28-7sc-507306
10 mg
$168.00
(0)

An autophagy inhibitor that blocks the degradation of PI3K, potentially influencing the PI3K/AKT/mTOR pathway and indirectly affecting the synthesis of proteins like MRP-S18C.

AZD8055

1009298-09-2sc-364424
sc-364424A
10 mg
50 mg
$163.00
$352.00
12
(2)

A selective mTOR kinase inhibitor that prevents both mTORC1 and mTORC2 activity, which could subsequently decrease the translation of proteins such as MRP-S18C.