MRP-L46 Inhibitors
MRP-L46 inhibitors belong to a specialized class of chemical compounds designed to target and modulate the activity of the MRP-L46 protein. The MRP-L46 protein, part of the ribosomal large subunit in eukaryotic cells, plays a crucial role in the process of protein synthesis. Specifically, it is involved in the peptidyl transferase activity during translation, where amino acids are linked together to form a polypeptide chain. The inhibitors are meticulously engineered to bind selectively to the MRP-L46 protein, disrupting its normal function and thereby impeding the accurate synthesis of proteins. This targeted interference at the molecular level holds significant implications for various cellular processes, as proteins are fundamental to the structure, function, and regulation of cells.
The development of MRP-L46 inhibitors represents a milestone in biochemistry and molecular biology research. By elucidating the intricate details of the MRP-L46 protein's role in the translation machinery, scientists have paved the way for designing compounds that can specifically modulate its activity. The inhibitors, often synthesized through rational drug design approaches, act as molecular tools for researchers to probe the complexities of protein synthesis. Understanding the nuances of MRP-L46 inhibition opens avenues for unraveling the broader landscape of cellular processes, facilitating not only basic research but also potential applications in areas such as biotechnology and molecular biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A is an immunosuppressant that binds to the cyclophilins which inhibits the activity of calcineurin, a phosphatase involved in the activation of T-cells. MRP-L46 is implicated in mitochondrial protein synthesis. By inhibiting calcineurin, T-cell activation is suppressed which can indirectly affect the energy demand and mitochondrial function, potentially impacting MRP-L46 activity. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $179.00 $612.00 $1203.00 $5202.00 $9364.00 | 26 | |
Oligomycin A is a specific inhibitor of the mitochondrial ATP synthase. By compromising ATP synthesis, it indirectly decreases the energy-dependent processes, including those involved in mitochondrial protein synthesis and function, thereby can lead to a reduced functional activity of MRP-L46 which is part of the mitochondrial ribosomal apparatus. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $90.00 | 10 | |
Chloramphenicol is an antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. As MRP-L46 is part of the mitochondrial ribosome, which is similar to bacterial ribosomes, chloramphenicol can potentially inhibit mitochondrial protein synthesis, thus reducing MRP-L46 functional activity in the process. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $57.00 $245.00 $831.00 $1331.00 | 4 | |
Erythromycin is another antibiotic that binds to the 50S subunit of bacterial ribosomes, inhibiting protein synthesis. Similar to chloramphenicol, erythromycin might inhibit mitochondrial protein synthesis, thereby affecting the function of MRP-L46. | ||||||
Doxycycline-d6 | 564-25-0 unlabeled | sc-218274 | 1 mg | $16500.00 | ||
Doxycycline is a tetracycline antibiotic that inhibits protein synthesis by binding to the 30S ribosomal subunit. It could also impact mitochondrial protein synthesis due to the similarities between bacterial and mitochondrial ribosomes, potentially decreasing MRP-L46 activity. | ||||||
Tetracycline | 60-54-8 | sc-205858 sc-205858A sc-205858B sc-205858C sc-205858D | 10 g 25 g 100 g 500 g 1 kg | $63.00 $94.00 $270.00 $417.00 $634.00 | 6 | |
Tetracycline is an antibiotic that inhibits protein synthesis by preventing the attachment of aminoacyl-tRNA to the ribosomal acceptor site. Its impact on mitochondrial ribosomes can indirectly lead to a reduction in MRP-L46 activity within the mitochondria. | ||||||
Puromycin | 53-79-2 | sc-205821 sc-205821A | 10 mg 25 mg | $166.00 $322.00 | 436 | |
Puromycin causes premature chain termination during protein synthesis by acting as an analog of aminoacyl-tRNA. This can cause a decrease in mitochondrial protein synthesis and thus potentially impact the functional activity of MRP-L46. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Dactinomycin intercalates into DNA, inhibiting RNA synthesis which is necessary for protein synthesis. The inhibition of mitochondrial RNA synthesis could indirectly lead to a decreased functional activity of MRP-L46, which is involved in mitochondrial protein synthesis. | ||||||
Actinonin | 13434-13-4 | sc-201289 sc-201289B | 5 mg 10 mg | $170.00 $385.00 | 3 | |
Actinonin is a peptide antibiotic that inhibits bacterial and mitochondrial peptidyl transferase. By interfering with peptide bond formation in the mitochondria, it could reduce the function of MRP-L46 in mitochondrial protein synthesis. | ||||||
Azithromycin | 83905-01-5 | sc-254949 sc-254949A sc-254949B sc-254949C sc-254949D | 25 mg 50 mg 500 mg 1 g 5 g | $52.00 $103.00 $260.00 $364.00 $728.00 | 17 | |
Azithromycin is a macrolide antibiotic that inhibits RNA-dependent protein synthesis by binding to the 50S subunit of the bacterial ribosome. It may similarly affect mitochondrial ribosomes, thereby potentially reducing the functional activity of MRP-L46. | ||||||