MRP-L38 Activators
MRP-L38 Activators primarily consist of chemical compounds that have a direct or indirect impact on the specific pathways in which MRP-L38 is involved. These activators, including Bortezomib, Cycloheximide, Actinomycin D, Rapamycin, Methotrexate, Puromycin, Anisomycin, Tunicamycin, Leptomycin B, Streptolydigin, and Emetine, can enhance the functional activity of MRP-L38 through specific signaling pathways.
Certain compounds, such as Bortezomib, Rapamycin, and Leptomycin B, operate through pathways related to protein degradation, mTOR signaling, and nuclear export, respectively. By inhibiting these processes, they can lead to an increase in MRP-L38 activity by decreasing its degradation, inhibiting mTOR signaling, or increasing its nuclear concentration. This allows MRP-L38 to continue performing its functions in ribosome biogenesis and protein synthesis. Another category of compounds that influence MRP-L38 activity are those targeting protein synthesis, such as Cycloheximide, Puromycin, Anisomycin, Aminoglycosides, and Emetine. By inhibiting protein synthesis, these compounds can trigger acompensatory response to enhance ribosome biogenesis and augment MRP-L38 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor that can potentially lead to an increase in the activity of MRP-L38 by preventing its degradation. This allows MRP-L38 to continue performing its functions in ribosome biogenesis and protein synthesis. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide is an inhibitor of protein synthesis. By inhibiting protein synthesis, it can trigger a compensatory response to increase ribosome biogenesis, therefore enhancing the functional activity of MRP-L38, a ribosomal protein. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D is an inhibitor of RNA synthesis. By inhibiting RNA synthesis, it may enhance the functional activity of MRP-L38 by triggering a compensatory response to increase ribosome biogenesis and protein synthesis. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an inhibitor of the mTOR pathway, which is involved in protein synthesis and ribosome biogenesis. By inhibiting this pathway, it can increase the functional activity of MRP-L38, a component of the ribosome. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate is a dihydrofolate reductase inhibitor that can lead to decreased availability of purine and pyrimidine nucleotides. This can trigger a compensatory response to increase ribosome biogenesis and protein synthesis, thereby potentially enhancing the functional activity of MRP-L38. | ||||||
Puromycin dihydrochloride | 58-58-2 | sc-108071 sc-108071B sc-108071C sc-108071A | 25 mg 250 mg 1 g 50 mg | $40.00 $210.00 $816.00 $65.00 | 394 | |
Puromycin is an analog of aminoacyl tRNAs, which causes premature chain termination during translation. This can enhance the functional activity of MRP-L38 by triggering a compensatory response to increase ribosome biogenesis and protein synthesis. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can potentially enhance the functional activity of MRP-L38 by triggering a compensatory response to increase ribosome biogenesis and protein synthesis. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin inhibits the formation of N-linked glycoproteins, a post-translational modification. This can potentially enhance the functional activity of MRP-L38 by triggering a compensatory response to increase protein synthesis and ribosome biogenesis. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $105.00 $408.00 $1224.00 | 35 | |
Leptomycin B is an inhibitor of nuclear export, potentially increasing the concentration of MRP-L38 in the nucleus and thereby enhancing its roles in ribosome biogenesis and protein synthesis. | ||||||
Streptonigrin | 3930-19-6 | sc-500892 sc-500892A | 1 mg 5 mg | $102.00 $357.00 | 1 | |
Streptolydigin is an inhibitor of RNA polymerase. By inhibiting RNA polymerase, it can potentially enhance the functional activity of MRP-L38 by triggering a compensatory response to increase ribosome biogenesis and protein synthesis. | ||||||