MRP-L35 Activators

The polyphenolic compound resveratrol interacts with sirtuins to promote mitochondrial biogenesis, creating a favorable environment for MRP-L35 activity. Similarly, 1,1-Dimethylbiguanide Hydrochloride, a widely studied biguanide, stimulates AMPK, which in turn catalyzes the creation of new mitochondria, providing additional platforms for the assembly and function of ribosomal proteins. Likewise, AICAR's activation of AMPK feeds into the same pathway, underscoring the role of mitochondrial biogenesis in ribosomal protein activity.

Thiazolidinediones such as pioglitazone and fibrates like bezafibrate exert their influence by altering the expression of mitochondrial genes, thereby potentially facilitating an increase in the components critical for mitochondrial protein synthesis, including ribosomal proteins. On the other hand, compounds like spermidine ensure the maintenance and efficiency of mitochondrial ribosomes by promoting autophagy, which is essential for the turnover and proper function of mitochondrial components. Meanwhile, molecules integral to mitochondrial metabolism, such as coenzyme Q10 and alpha-lipoic acid, indirectly support the synthesis activities of ribosomal proteins by ensuring a steady supply of energy, which is crucial for the demanding task of protein synthesis. Nicotinamide riboside, a precursor to NAD+, enhances mitochondrial health, thereby contributing to the optimal performance of ribosomal proteins. Furthermore, epicatechin increases mitochondrial biogenesis through the upregulation of PGC-1α, leading to an amplified presence of mitochondrial ribosomes ready for protein synthesis.