MrgB8 Activators
MrgB8 Activators encompass a range of chemical compounds that indirectly augment the functional activity of MrgB8, a protein primarily associated with sensory neuron signaling and the perception of pain. This enhancement of MrgB8's activity arises through the modulation of various receptors and signaling pathways involved in sensory processing. Capsaicin and Resiniferatoxin, by targeting TRPV1 receptors, lead to an elevated neuronal activity, thereby indirectly facilitating the role of MrgB8 in pain signaling pathways. Similarly, Menthol, through its action on TRPM8 receptors, influences neurons that express MrgB8, potentially augmenting its function in cool sensation and pain modulation. Additionally, Cannabidiol (CBD), known for interacting with the endocannabinoid system, affects sensory neurons including those expressing MrgB8, thereby enhancing its activity in pain pathways. Furthermore, Lidocaine, by blocking sodium channels, alters neuron firing patterns, which could lead to an enhanced functional role of MrgB8 in pain perception pathways.
Moreover, the activity of MrgB8 is influenced by substances that modulate inflammatory responses and cellular states. Compounds like Rutin, Omega-3 Fatty Acids, and Curcumin, through their influence on inflammation, indirectly affect sensory neurons expressing MrgB8, thereby enhancing its role in pain signaling. Quercetin and Alpha-Lipoic Acid, recognized for their anti-inflammatory and antioxidant properties, potentially modulate neuronal responses, further augmenting MrgB8's function in sensory signaling pathways. Palmitoylethanolamide (PEA), involved in endocannabinoid signaling, and Capsazepine, a TRPV1 antagonist, contribute to the modulation of pain pathways, indirectly influencing MrgB8's activity in sensory neurons. Collectively, these MrgB8 Activators, through their targeted effects on neuronal activity and pain signaling pathways, facilitate the enhancement of MrgB8-mediated functions in sensory perception and pain modulation without necessitating direct activation or upregulation of the protein itself.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin targets TRPV1 receptors, which are involved in pain and thermal sensation pathways. This interaction indirectly enhances MrgB8 activity, as MrgB8 is implicated in sensory neuron signaling, particularly in pain perception. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $39.00 $68.00 | ||
Menthol acts as an agonist at TRPM8 receptors, involved in cool sensation and pain modulation. Its action can influence neurons expressing MrgB8, indirectly enhancing MrgB8's role in sensory signaling. | ||||||
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $51.00 $131.00 | ||
Lidocaine blocks sodium channels, affecting neuron firing. This action can alter the response in pain pathways where MrgB8 is active, potentially enhancing its functional role. | ||||||
Rutin trihydrate | 250249-75-3 | sc-204897 sc-204897A sc-204897B | 5 g 50 g 100 g | $57.00 $72.00 $126.00 | 7 | |
Rutin modulates inflammatory responses, influencing sensory neurons and indirectly enhancing MrgB8's function in pain signaling pathways. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $94.00 $210.00 $1779.00 $8021.00 $16657.00 | 11 | |
Omega-3 fatty acids influence anti-inflammatory processes, indirectly affecting neurons expressing MrgB8 and enhancing its role in pain signaling pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin affects inflammatory pathways, potentially influencing MrgB8-expressing neurons and enhancing MrgB8's functional activity in pain signaling. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, with its anti-inflammatory and antioxidant properties, can modulate neuronal responses, indirectly enhancing MrgB8's role in sensory signaling pathways. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Alpha-Lipoic Acid, by affecting cellular redox states, can modulate neuronal activity. This modulation indirectly influences MrgB8's function in sensory neurons involved in pain perception. | ||||||
Palmitoylethanolamide | 544-31-0 | sc-202754 sc-202754A sc-202754B sc-202754C sc-202754D | 10 mg 50 mg 500 mg 1 g 10 g | $80.00 $243.00 $2091.00 $3339.00 $16657.00 | ||
PEA, involved in endocannabinoid signaling, modulates nociceptive neurons. This modulation can potentially enhance MrgB8's activity in pain signaling pathways. | ||||||
Capsazepine | 138977-28-3 | sc-201098 sc-201098A | 5 mg 25 mg | $148.00 $459.00 | 11 | |
138977-28-3 Capsazepine, a TRPV1 antagonist, modulates pain pathways by altering TRPV1-mediated signaling. This alteration can indirectly influence MrgB8 function in sensory neurons, particularly in pathways related to pain perception. | ||||||