MPP9 Activators
In the cellular landscape, MPP9 activators primarily focus on signaling pathways and processes associated with cell-cell junctions, which are pivotal for tissue integrity and cell communication. Adherens junctions and tight junctions, for instance, are crucial for epithelial barrier function. The EGFR pathway, stimulated by EGF, directly modulates adherens junction dynamics through actin cytoskeleton rearrangements. Similarly, PKC, activated by agents like PMA, is integral for tight junction assembly and maintenance. Given MPP9's hypothesized association with the MAGUK family, these junctions may be a central functional platform for the protein.
Furthermore, synaptic structures in neurons, another domain for MPP9, rely on calcium signaling for synapse formation and function. Ionomycin's effect on elevating intracellular calcium can thus modulate MPP9's role in synapses. Compounds like Forskolin, Rolipram, Caffeine, and IBMX emphasize the importance of cyclic nucleotides (cAMP and cGMP) in regulating cell-cell junction dynamics. MPP9 is intricately involved in these junctions, its functional modulation by these cyclic nucleotides is evident. In essence, MPP9 activators offer a window into the complex dynamics of cell-cell junctions. While the precise role of MPP9 within these structures remains to be detailed, these chemicals provide tools to dissect its function and regulation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase, leading to increased cAMP levels. Elevated cAMP can activate PKA, which modulates the assembly and function of cell-cell junctions, potentially affecting the function of MPP9 within these junctions. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Elevates intracellular calcium. Calcium ions play a role in synapse formation and function, which could implicate MPP9 if it's associated with synaptic structures. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates PKC which is integral to tight junction assembly and regulation. If MPP9 is involved in tight junction dynamics, its function could be influenced by PKC activation. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
LPA receptor activation affects tight junction permeability. If MPP9 is crucial to tight junction structure or regulation, it may be modulated by LPA. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
By inhibiting PDE4 and increasing cAMP levels, Rolipram can indirectly influence cell-cell junction assembly and dynamics, affecting MPP9's potential role within these structures. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Elevates cAMP levels by inhibiting its degradation, influencing cell-cell junctions and potentially modulating MPP9's function within these junctions. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Elevates both cAMP and cGMP by inhibiting phosphodiesterases. This modulation can influence cell-cell junctions, potentially affecting MPP9's function. | ||||||