MPP7 Inhibitors
MPP7 inhibitors belong to a distinct chemical class of compounds known for their role in modulating cellular processes by targeting the MPP7 protein. MPP7, or Membrane Protein, Palmitoylated 7, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. These proteins are essential for cell-to-cell communication and the organization of specialized membrane structures, such as tight junctions and adherens junctions, which are crucial for maintaining tissue integrity and cell polarity. MPP7, in particular, plays a pivotal role in anchoring transmembrane proteins and cytoskeletal elements to these junctional complexes, thereby ensuring cell stability and tissue function.
MPP7 inhibitors are designed to interfere with the function of the MPP7 protein by binding to specific sites on the protein's structure, often at the interface between the protein and its binding partners. By doing so, they disrupt the normal protein-protein interactions that MPP7 mediates, leading to altered junctional organization and cellular behavior. These inhibitors may function as valuable research tools, aiding scientists in elucidating the intricate mechanisms of cell adhesion, polarity, and signaling.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A potent inhibitor of phosphoinositide 3-kinases (PI3K), which may affect MPP7's associated signaling pathways by altering the phosphoinositide balance within the cell. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
A selective inhibitor of MEK1/2, which could alter the ERK/MAPK signaling pathway, potentially influencing the cellular processes that MPP7 is part of. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A pyridinyl imidazole compound known to inhibit p38 MAP Kinase, which can affect the signaling pathways regulating cytoskeletal dynamics where MPP7 is implicated. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An anthrapyrazolone inhibitor of c-Jun N-terminal kinase (JNK), which may modulate the activity of proteins that interact with MPP7 or its regulatory mechanisms. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A steroidal furan compound that acts as an inhibitor of PI3K, which may indirectly affect the pathways involving MPP7 by altering kinase activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
A macrolide compound that binds to FKBP12 and inhibits mTOR, which can influence the signaling pathways that MPP7 may be involved in, such as cell growth and proliferation. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
A potent inhibitor of protein kinase C (PKC), which is involved in various signaling cascades that could intersect with MPP7's role in the cell. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
A cell-permeable, highly potent and selective inhibitor of Rho-associated, coiled-coil containing protein kinase (ROCK), which may impact MPP7-related pathways influencing cell shape and motility. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
A selective inhibitor of Src family tyrosine kinases, which could modify signaling pathways or cellular interactions involving MPP7. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
A selective inhibitor of MEK that prevents the activation of MAPK/ERK, potentially altering cellular processes that are regulated by MPP7. | ||||||