MOXD1 Inhibitors
MOXD1 inhibitors are a class of chemical compounds designed to target and modulate the activity of the enzyme known as MOXD1 (Monooxygenase DBH-like 1), also referred to as MOX or AOF1 (Amidoxime Reducing Component 1). MOXD1 is a flavin-dependent monooxygenase enzyme found in various tissues, including the liver and kidneys, and plays a crucial role in the oxidative metabolism of xenobiotics and endogenous substrates. The primary function of MOXD1 is to catalyze the NADH-dependent hydroxylation of amidoximes to their corresponding aldehydes, participating in various metabolic pathways. Inhibition of MOXD1 by specific chemical agents can provide valuable insights into the biochemical and physiological processes involving this enzyme.
MOXD1 inhibitors are typically small molecules that interact with the active site of the enzyme, disrupting its catalytic function. These inhibitors may function by binding to the flavin cofactor or other critical residues within the enzyme's active site, thereby preventing the conversion of amidoximes to aldehydes. By interfering with MOXD1's enzymatic activity, these inhibitors can be valuable tools for researchers studying the pathways in which MOXD1 is involved.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $41.00 | 4 | |
Inhibits cyclooxygenase enzymes, reducing prostaglandin synthesis, and exerting anti-inflammatory and antiplatelet effects. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Tyrosine kinase inhibitor targeting BCR-ABL, studied in the research of chronic myeloid leukemia (CML) and other cancers. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $66.00 | 4 | |
Proton pump inhibitor that suppresses gastric acid secretion by inhibiting the H+/K+ ATPase pump in the stomach lining. | ||||||
Allopurinol | 315-30-0 | sc-207272 | 25 g | $128.00 | ||
Inhibits xanthine oxidase, reducing uric acid production and used in the therapy of gout and hyperuricemia. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Improves insulin sensitivity, primarily by suppressing hepatic gluconeogenesis and enhancing glucose uptake in muscles. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $30.00 $87.00 $132.00 $434.00 | 13 | |
HMG-CoA reductase inhibitor, lowering cholesterol levels by inhibiting the synthesis of mevalonate and subsequent cholesterol production. | ||||||
Donepezil | 120014-06-4 | sc-279006 | 10 mg | $73.00 | 3 | |
Acetylcholinesterase (AChE) inhibitor, used in Alzheimer's disease therapy by increasing acetylcholine levels in the brain. | ||||||
Ritonavir | 155213-67-5 | sc-208310 | 10 mg | $122.00 | 7 | |
HIV protease inhibitor, disrupting the processing of viral polyproteins and inhibiting HIV replication. | ||||||
Ciprofloxacin | 85721-33-1 | sc-217900 | 1 g | $42.00 | 8 | |
Inhibits bacterial DNA gyrase and topoisomerase IV, blocking DNA replication and repair in bacteria. | ||||||
Fluconazole | 86386-73-4 | sc-205698 sc-205698A | 500 mg 1 g | $53.00 $84.00 | 14 | |
Antifungal agent that inhibits the enzyme lanosterol 14α-demethylase, disrupting fungal cell membrane synthesis. | ||||||