MOAP1 Inhibitors
Chemical inhibitors of MOAP1 target various signaling pathways to inhibit the functional activity of this apoptosis-related protein. LY294002 and Wortmannin, both PI3K inhibitors, inhibit the PI3K/Akt pathway, a crucial cell survival pathway. Inhibition of this pathway leads to reduced survival signaling and enhances apoptotic processes that MOAP1 is known to be involved in. Similarly, Triciribine, an Akt inhibitor, suppresses Akt activity and promotes apoptosis, thereby inhibiting MOAP1, which is dependent on the signaling for its anti-apoptotic interactions. The MEK inhibitors U0126 and PD98059, by inhibiting the MAPK/ERK pathway, also suppress survival signals. This suppression facilitates apoptotic processes, indirectly inhibiting MOAP1, which relies on these signals for its function.
In addition to these, Rapamycin acts as an mTOR inhibitor and disrupts mTOR signaling, contributing to the inhibition of MOAP1 by favoring apoptosis over cell survival. SB203580 and PD169316, both p38 MAPK inhibitors, hinder the p38 MAPK signaling pathway, leading to the enhancement of apoptotic signaling and functional inhibition of MOAP1. The JNK inhibitor SP600125 limits JNK signaling involved in stress-induced apoptosis, which can lead to apoptosis, a state where MOAP1's function is inhibited. Moreover, Chelerythrine's inhibition of the protein kinase C (PKC) pathway favors apoptotic pathways over survival, which is where MOAP1 exerts its effects. Roscovitine inhibits cyclin-dependent kinases, arresting the cell cycle and promoting apoptosis, thereby inhibiting MOAP1. Lastly, Z-VAD-FMK, typically known as a pan-caspase inhibitor, paradoxically results in the functional inhibition of MOAP1 by blocking the caspases that MOAP1 interacts with, thus preventing MOAP1 from exerting its pro-apoptotic function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can inhibit the PI3K/Akt pathway. MOAP1 is involved in apoptosis pathways, and inhibition of PI3K/Akt can lead to the activation of pro-apoptotic factors, thereby inhibiting MOAP1 function by promoting apoptosis. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK inhibitor that can inhibit the MAPK/ERK pathway. MOAP1 is associated with cell death regulation, and the inhibition of MEK, upstream of ERK, can result in the suppression of survival signals, thus indirectly inhibiting MOAP1 by facilitating apoptotic processes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that can inhibit the p38 MAPK signaling pathway. MOAP1 has been implicated in apoptosis, and the inhibition of p38 MAPK can enhance apoptosis, potentially inhibiting MOAP1 activity by disrupting its anti-apoptotic interactions. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor that can inhibit the JNK signaling pathway. Since MOAP1 plays a role in apoptosis and JNK signaling is involved in stress-induced apoptosis, inhibiting JNK can lead to apoptosis, which may inhibit MOAP1 by promoting cell death mechanisms. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor that can inhibit the PI3K/Akt pathway. By inhibiting PI3K, downstream signaling leading to cell survival is diminished, which can indirectly inhibit MOAP1 by favoring apoptotic signaling pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that can inhibit the MAPK/ERK pathway. Inhibition of this pathway can result in decreased survival signaling and can indirectly inhibit MOAP1 by promoting apoptosis, where MOAP1 is involved. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that can inhibit the mTOR signaling pathway. MOAP1 is implicated in cell death, and inhibition of mTOR signaling can lead to increased apoptotic processes, thereby inhibiting MOAP1 function. | ||||||
Z-VAD-FMK | 187389-52-2 | sc-3067 | 500 µg | $74.00 | 256 | |
Z-VAD-FMK is a pan-caspase inhibitor that, while typically preventing apoptosis, can result in the functional inhibition of MOAP1 by inhibiting caspases that MOAP1 is known to interact with and that are essential for its pro-apoptotic function. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Triciribine is an Akt inhibitor that can inhibit the PI3K/Akt pathway. Since MOAP1 is associated with apoptotic pathways, the inhibition of Akt can lead to an increase in apoptotic signaling, indirectly inhibiting MOAP1. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine is a cyclin-dependent kinase inhibitor that can inhibit the cell cycle. By inhibiting cell cycle progression, it can indirectly inhibit MOAP1 by promoting apoptosis, as MOAP1 is known to be involved in apoptosis. | ||||||