Mkk2 Inhibitors
Mkk2 inhibitors are a class of chemicals that can potentially inhibit the function of the Mkk2 protein, a dual-specificity kinase involved in the mitogen-activated protein kinase (MAPK) signaling pathway. These inhibitors can directly target Mkk2 or indirectly influence its activity by modulating the upstream or downstream signaling pathways. One group of Mkk2 inhibitors includes compounds that specifically target the MAPK signaling pathways. PD 98059 and U0126 are synthetic compounds that selectively inhibit MEK1, the upstream kinase of Mkk2. By blocking MEK1 activation and subsequent phosphorylation of Mkk2, these inhibitors effectively inhibit Mkk2-mediated signaling. Similarly, SB 203580, SB 202190, VX 745, Doramapimod, and SB 239063 are synthetic compounds that target the p38 MAPK signaling pathway. They inhibit p38 MAPK, which phosphorylates and activates Mkk2, leading to the inhibition of Mkk2-mediated signaling.
Another group of inhibitors includes compounds that target specific signaling pathways related to Mkk2. SP600125 is a synthetic compound that selectively inhibits JNK, a kinase involved in the JNK signaling pathway. By preventing JNK activation and downstream phosphorylation of Mkk2, SP600125 inhibits Mkk2-mediated signaling. LY 294002 and Wortmannin are compounds that target the phosphatidylinositol 3-kinase (PI3K) signaling pathway. They inhibit PI3K, blocking the activation of downstream kinases, including Mkk2, and inhibiting their signaling cascades. ERK Inhibitor II, FR180204 is a synthetic compound that specifically targets the ERK1/2 MAPK signaling pathway. It acts as a selective inhibitor of ERK1/2, preventing their activation and subsequent phosphorylation of Mkk2, leading to the inhibition of Mkk2-mediated signaling. In summary, Mkk2 inhibitors are a diverse group of chemicals that can directly target Mkk2 or indirectly influence its activity by modulating the MAPK signaling pathways or related signaling cascades. These inhibitors provide valuable tools for studying the role of Mkk2 in cellular processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 is a synthetic compound that can inhibit Mkk2 by specifically targeting the mitogen-activated protein kinase (MAPK) signaling pathway. It acts as a selective inhibitor of MEK1, the upstream kinase of Mkk2, preventing its activation and subsequent phosphorylation of Mkk2, leading to the inhibition of Mkk2-mediated signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB 203580 is a synthetic compound that can inhibit Mkk2 by targeting the p38 MAPK signaling pathway. It specifically inhibits p38 MAPK, which phosphorylates and activates Mkk2, leading to the inhibition of Mkk2-mediated signaling. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a synthetic compound that can inhibit Mkk2 by specifically targeting the c-Jun N-terminal kinase (JNK) signaling pathway. It acts as a selective inhibitor of JNK, preventing its activation and downstream phosphorylation of Mkk2, leading to the inhibition of Mkk2-mediated signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY 294002 is a synthetic compound that can inhibit Mkk2 by targeting the phosphatidylinositol 3-kinase (PI3K) signaling pathway. It acts as a reversible inhibitor of PI3K, blocking the activation of downstream kinases, including Mkk2, and inhibiting their signaling cascades. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a natural compound that can inhibit Mkk2 by targeting the PI3K signaling pathway. It irreversibly inhibits PI3K, preventing the activation of downstream kinases, including Mkk2, and inhibiting their signaling cascades. | ||||||
SB 202190 | 152121-30-7 | sc-202334 sc-202334A sc-202334B | 1 mg 5 mg 25 mg | $31.00 $128.00 $454.00 | 45 | |
SB 202190 is a synthetic compound that can inhibit Mkk2 by specifically targeting the p38 MAPK signaling pathway. It acts as a selective inhibitor of p38 MAPK, blocking its activation and downstream phosphorylation of Mkk2, leading to the inhibition of Mkk2-mediated signaling. | ||||||
VX 745 | 209410-46-8 | sc-361401 sc-361401A | 10 mg 50 mg | $183.00 $842.00 | 4 | |
VX 745 is a synthetic compound that can inhibit Mkk2 by targeting the p38 MAPK signaling pathway. It acts as a selective inhibitor of p38 MAPK, preventing its activation and subsequent phosphorylation of Mkk2, leading to the inhibition of Mkk2-mediated signaling. | ||||||
Doramapimod | 285983-48-4 | sc-300502 sc-300502A sc-300502B | 25 mg 50 mg 100 mg | $149.00 $281.00 $459.00 | 2 | |
Doramapimod is a synthetic compound that can inhibit Mkk2 by specifically targeting the p38 MAPK signaling pathway. It acts as a selective inhibitor of p38 MAPK, blocking its activation and downstream phosphorylation of Mkk2, leading to the inhibition of Mkk2-mediated signaling. | ||||||
SB 239063 | 193551-21-2 | sc-220094B sc-220094 sc-220094A | 500 µg 5 mg 25 mg | $119.00 $162.00 $645.00 | 7 | |
SB 239063 is a synthetic compound that can inhibit Mkk2 by targeting the p38 MAPK signaling pathway. It acts as a selective inhibitor of p38 MAPK, preventing its activation and subsequent phosphorylation of Mkk2, leading to the inhibition of Mkk2-mediated signaling. | ||||||
ERK Inhibitor II, FR180204 | 865362-74-9 | sc-203945 sc-203945A sc-203945B sc-203945C | 1 mg 5 mg 10 mg 50 mg | $110.00 $165.00 $239.00 $942.00 | 45 | |
ERK Inhibitor II, FR180204 is a synthetic compound that can inhibit Mkk2 by targeting the ERK1/2 MAPK signaling pathway. It acts as a selective inhibitor of ERK1/2, preventing their activation and subsequent phosphorylation of Mkk2, leading to the inhibition of Mkk2-mediated signaling. | ||||||