MIS Activators
Common MIS Activators include, but are not limited to Diethylstilbestrol CAS 56-53-1, Di-n-butyl phthalate CAS 84-74-2, Letrozole CAS 112809-51-5, Clomiphene Citrate CAS 50-41-9 and Ketoconazole CAS 65277-42-1.
MIS, also referred to as anti-Müllerian hormone (AMH), is a glycoprotein hormone of the transforming growth factor-beta (TGF-β) family. It plays an essential role in male and female reproductive development. In males, MIS is responsible for the regression of the Müllerian ducts, structures that would otherwise develop into the female reproductive tract. In females, AMH is produced by the granulosa cells of ovarian follicles and serves as a marker of ovarian reserve, reflecting the number of remaining egg-containing follicles in the ovaries. The level of AMH in a woman's blood is often used as an indicator of her ovarian function, fertility, and the onset of menopause.
The chemical class of MIS Activators encompasses molecules designed to enhance the expression, release, or activity of MIS/AMH. These activators might function by stimulating the transcription of the MIS/AMH gene, promoting the secretion of the hormone, or increasing its binding and activity at its receptors. By amplifying the effects of MIS/AMH, these activators can modulate reproductive developmental processes, especially those where the hormone naturally has a regulatory role. In a research context, MIS/AMH activators can be valuable tools for probing the hormone's functions in reproductive biology and its interactions with other hormonal pathways. Investigating these activators helps in elucidating the intricate balance of factors that govern reproductive development and function, offering deeper insights into the complexities of human biology at the molecular and cellular levels.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Diethylstilbestrol | 56-53-1 | sc-204720 sc-204720A sc-204720B sc-204720C sc-204720D | 1 g 5 g 25 g 50 g 100 g | $71.00 $287.00 $547.00 $1098.00 $2185.00 | 3 | |
DES, a synthetic estrogen, could influence gonadal function and steroidogenesis. It might modulate MIS expression as part of its broader effects on the reproductive system. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
BPA, an endocrine disruptor, could interfere with hormone signaling pathways in the gonads, potentially leading to altered MIS expression in response to disrupted endocrine balance. | ||||||
Di-n-butyl phthalate | 84-74-2 | sc-257307 sc-257307A sc-257307B | 5 g 25 g 1 kg | $41.00 $52.00 $104.00 | 1 | |
DBP, another endocrine disruptor, might influence MIS expression by affecting steroidogenic pathways or direct effects on gonadal tissues. | ||||||
Letrozole | 112809-51-5 | sc-204791 sc-204791A | 25 mg 50 mg | $87.00 $147.00 | 5 | |
Letrozole, an aromatase inhibitor, might increase MIS levels by altering estrogen synthesis, affecting the feedback mechanisms in the ovary. | ||||||
Clomiphene Citrate | 50-41-9 | sc-205636 sc-205636A | 1 g 5 g | $84.00 $176.00 | 1 | |
Clomiphene citrate stimulates ovulation by antagonizing estrogen receptors. This might induce MIS expression as part of the follicular response. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $63.00 $265.00 | 21 | |
Ketoconazole inhibits steroid synthesis. By altering steroid levels, it might influence MIS expression in gonadal tissues. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin might modulate MIS levels by affecting insulin signaling and its subsequent effects on the ovary. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $109.00 | 3 | |
Spironolactone, an aldosterone antagonist, has anti-androgenic properties. It might influence MIS expression by modulating androgenic effects on the ovary. | ||||||
Flutamide | 13311-84-7 | sc-204757 sc-204757A sc-204757D sc-204757B sc-204757C | 1 g 5 g 25 g 500 g 1 kg | $47.00 $156.00 $171.00 $525.00 $941.00 | 4 | |
Flutamide, an androgen receptor antagonist, might modulate AMH expression in response to altered androgen signaling in the gonads. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone might influence AMH levels due to its effects on adrenal and ovarian steroidogenesis, potentially impacting AMH regulation. | ||||||