MiRP1 Activators
MiRP1, also known as KCNE2, is a protein that functions as a regulatory subunit of potassium channels. Specifically, MiRP1 associates with the voltage-gated potassium channel complexes and modulates their gating properties, which is crucial for maintaining the electrical excitability of cells, particularly in cardiac and epithelial tissues. MiRP1 activators would be a class of chemicals that can enhance the functional activity of these potassium channel complexes either by directly interacting with MiRP1 or through indirect pathways.
Direct activators of MiRP1 bind to specific sites on the protein, inducing conformational changes that lead to an increase in the channel's open probability or modify the kinetics of opening and closing, which in turn could increase potassium ion conductance. These activators might stabilize the association between MiRP1 and its partner potassium channel proteins, such as KCNQ1, enhancing the overall function of the channel complex. Indirect activators influence the expression levels of MiRP1 by upregulating the KCNE2 gene, leading to a higher concentration of the regulatory subunit within the cell and potentially more active potassium channels as a result. Other indirect mechanisms might involve the modulation of intracellular signaling pathways that affect the trafficking, localization, or degradation of MiRP1, thereby influencing the number of functional channels on the cell surface.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is a calcium channel blocker that can indirectly impact MiRP1 by modifying the membrane potential and altering the function of ion channels, including hERG. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine is a calcium channel blocker that can indirectly modulate MiRP1 by altering the membrane potential and the function of ion channels, including hERG. | ||||||
Glyburide (Glibenclamide) | 10238-21-8 | sc-200982 sc-200982A sc-200982D sc-200982B sc-200982C | 1 g 5 g 25 g 100 g 500 g | $46.00 $61.00 $117.00 $173.00 $530.00 | 36 | |
Bay K 8644 is a calcium channel agonist that can indirectly influence MiRP1 by altering the membrane potential and thereby modulating the function of potassium channels, including hERG. | ||||||
Chromanol 293B | 163163-23-3 | sc-203889 sc-203889A | 10 mg 50 mg | $182.00 $774.00 | 1 | |
Chromanol 293B is an IKs potassium channel blocker. By blocking the IKs channel, it can indirectly modulate MiRP1. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that can indirectly modulate MiRP1 by causing changes in the membrane potential and thereby impacting the function of potassium channels, including hERG. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $326.00 $485.00 | 3 | |
Noradrenaline can indirectly influence MiRP1 by causing changes in the membrane potential and thus altering the function of potassium channels, including hERG. | ||||||
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
Propranolol is a beta-adrenergic antagonist that can indirectly modulate MiRP1 by modifying the membrane potential and altering the function of potassium channels, including hERG. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $516.00 | |||
Ouabain inhibits Na+/K+-ATPase, which indirectly impacts MiRP1 by changing the membrane potential and altering the function of potassium channels, including hERG. | ||||||
12β-Hydroxydigitoxin | 20830-75-5 | sc-213604 sc-213604A | 1 g 5 g | $143.00 $694.00 | ||
12β-Hydroxydigitoxin is a cardiac glycoside that inhibits Na+/K+-ATPase, indirectly modulating MiRP1 by changing the membrane potential and altering the function of potassium channels, including hERG. | ||||||