12β-Hydroxydigitoxin (CAS 20830-75-5)
QUICK LINKS
12β-Hydroxydigitoxin is a cardiac glycoside that functions by inhibiting the sodium-potassium ATPase pump in cardiac muscle cells. This inhibition leads to an increase in intracellular sodium levels, which subsequently reduces the activity of the sodium-calcium exchanger. As a result, there is an accumulation of intracellular calcium, leading to increased contractility of the cardiac muscle. 12β-Hydroxydigitoxin′s mechanism of action involves binding to the alpha subunit of the sodium-potassium ATPase pump, thereby disrupting its normal function. This disruption ultimately leads to changes in ion concentrations within the cardiac muscle cells, resulting in enhanced contractile force. 12β-Hydroxydigitoxin may have a longer duration of action compared to other cardiac glycosides, making it a unique for studying the regulation of cardiac muscle contraction.
12β-Hydroxydigitoxin (CAS 20830-75-5) References
- Inhibition of rat brain ecto-atpase activity by various drugs. | Horvat, A., et al. 2006. Gen Physiol Biophys. 25: 91-105. PMID: 16714778
- Influence of a time-restricted feeding schedule on the daily rhythm of abcb1a gene expression and its function in rat intestine. | Hayashi, Y., et al. 2010. J Pharmacol Exp Ther. 335: 418-23. PMID: 20668054
- Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research. | Robery, S., et al. 2011. PLoS One. 6: e24439. PMID: 21931717
- Repurposing the cardiac glycoside digoxin to stimulate myelin regeneration in chemically-induced and immune-mediated mouse models of multiple sclerosis. | Titus, HE., et al. 2022. Glia. 70: 1950-1970. PMID: 35809238
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
12β-Hydroxydigitoxin, 1 g | sc-213604 | 1 g | $143.00 | |||
12β-Hydroxydigitoxin, 5 g | sc-213604A | 5 g | $694.00 |