MIER1 Inhibitors
Chemical inhibitors of MIER1 function by disrupting the protein's interactions with histone deacetylases (HDACs), which are essential for its role in chromatin remodeling and gene expression regulation. Trichostatin A, Suberoylanilide hydroxamic acid (SAHA), and MS-275 target the deacetylase activity of HDAC1, a known associate of MIER1. By preventing the deacetylation process, these inhibitors maintain a hyperacetylated state in histones, which is associated with an open chromatin conformation and often leads to increased transcription. Since MIER1's regulatory actions are contingent upon the remodeling capabilities provided through HDAC1, its functional capacity is hindered when HDAC1 is inhibited. Similarly, Mocetinostat, with its specificity towards HDAC1 and 3, and Romidepsin, a potent HDAC1 inhibitor, disrupt the normal interplay between MIER1 and these deacetylases, effectively inhibiting the regulatory influence of MIER1 on gene expression.
Further along this vein, Panobinostat, as a broad-spectrum HDAC inhibitor, and Chidamide, with selective inhibition properties, would preclude MIER1 from recruiting HDAC1 to the chromatin, thereby inhibiting MIER1's chromatin modification functions. Belinostat and Valproic acid also inhibit HDAC activity, which in turn would prevent MIER1 from exerting its effects on chromatin architecture and gene expression. LMK-235, although primarily an HDAC4 and HDAC5 inhibitor, could indirectly inhibit MIER1 by altering the overall chromatin landscape and gene expression patterns. Tacedinaline and Scriptaid, both HDAC inhibitors, would interfere with MIER1's ability to regulate gene expression by maintaining a state of histone acetylation that is not conducive to MIER1's function of chromatin compaction and gene repression, thus impeding MIER1's role in gene regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. MIER1 is known to interact with histone deacetylase 1 (HDAC1). Inhibition of HDAC1 by Trichostatin A could prevent the deacetylation of histones and non-histone proteins that MIER1 may regulate, leading to inhibition of MIER1's ability to modify chromatin and gene expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
SAHA, also known as Vorinostat, is another histone deacetylase inhibitor. By inhibiting HDACs, SAHA can alter chromatin structure and impede MIER1's interaction with HDAC1, leading to inhibition of MIER1's function in gene regulation. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
MS-275 is a selective inhibitor of HDAC1. It can inhibit the interaction between MIER1 and HDAC1, thereby inhibiting the ability of MIER1 to affect chromatin structure and function. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $214.00 $247.00 $1463.00 | 2 | |
Mocetinostat is an HDAC inhibitor with specificity towards HDAC1 and 3. Since MIER1's function is associated with HDAC1, inhibition of HDAC activity by Mocetinostat would disrupt MIER1's role in chromatin remodeling and gene expression. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
Romidepsin is a potent HDAC1 inhibitor, which would inhibit the deacetylase activity that MIER1 relies on to exert its effects on chromatin, resulting in the inhibition of MIER1's regulatory functions. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
Panobinostat is a broad-spectrum HDAC inhibitor that would prevent MIER1 from recruiting HDAC1 to chromatin, thus inhibiting the ability of MIER1 to regulate gene expression through chromatin modification. | ||||||
Chidamide | 743420-02-2 | sc-364462 sc-364462A sc-364462B | 1 mg 5 mg 25 mg | $62.00 $250.00 $1196.00 | ||
Chidamide selectively inhibits HDACs, including HDAC1. By inhibiting HDAC activity, Chidamide would impede the regulatory role of MIER1 in gene expression by maintaining an acetylated state of histones. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $156.00 $572.00 | ||
Belinostat inhibits HDAC activity, which could prevent MIER1 from interacting with HDAC1, thus inhibiting the ability of MIER1 to modify chromatin structure and function. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid is an HDAC inhibitor that would disrupt the interaction between MIER1 and HDAC1, thereby inhibiting MIER1's chromatin-modifying functions. | ||||||
CI 994 | 112522-64-2 | sc-205245 sc-205245A | 10 mg 50 mg | $99.00 $536.00 | 1 | |
Tacedinaline is an HDAC inhibitor that could interfere with MIER1's ability to regulate gene expression through modification of chromatin structure by preventing deacetylation. | ||||||