MIC1 Activators
MIC1 Activators are a class of chemical compounds that specifically enhance the functional activity of MIC1, a protein directly involved in the cAMP-PKA pathway. These activators primarily work by promoting the levels of cAMP, a critical second messenger involved in a multitude of biological processes. Epinephrine, Isoproterenol, PGE2, PACAP, GLP-1, VIP, Dopamine, Histamine, and Serotonin all enhance cAMP levels by activating specific receptors involved in the cAMP-PKA pathway that MIC1 is a part of. The increased cAMP levels trigger PKA activation, which leads to an increase in the functional activity of MIC1.
Certain MIC1 Activators function by inhibiting the breakdown of cAMP, leading to elevated levels of this second messenger in the cell. Rolipram and IBMX, for instance, are known to inhibit phosphodiesterase, the enzyme responsible for degrading cAMP. This inhibition results in increased cAMP levels, which in turn trigger PKA activation. As PKA is a key component of the cAMP-PKA pathway, this effect directly leads to enhanced functional activity of MIC1, a critical protein in this pathway. Therefore, the entire class of MIC1 Activators ensures a range of mechanisms to enhance cAMP levels and, consequently, the functional activity of MIC1.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine activates the β-adrenoceptor, which is involved in the cAMP-PKA pathway. This pathway can ultimately lead to the increased functional activity of MIC1. Higher cAMP levels promote PKA activation, which triggers a series of events that enhance MIC1 activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin stimulates adenylate cyclase, leading to elevated cAMP levels. The cAMP-PKA pathway, in which MIC1 is involved, is triggered by this increase, thus enhancing the functional activity of MIC1. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a β-adrenoceptor agonist that promotes cAMP levels. The increased cAMP triggers the cAMP-PKA pathway, enhancing MIC1 activity, as MIC1 is directly involved in this pathway. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase-4, preventing cAMP breakdown. The resulting increase in cAMP levels triggers the cAMP-PKA pathway, leading to enhanced MIC1 activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a phosphodiesterase inhibitor, preventing the breakdown of cAMP. The increased cAMP levels lead to PKA activation and the subsequent enhancement of the cAMP-PKA pathway that MIC1 is a part of. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 activates the EP2 receptor, which is involved in the cAMP-PKA pathway. This activation can enhance MIC1 activity by promoting cAMP levels and PKA activation. | ||||||
PACAP(6-38) | 137061-48-4 | sc-391136 sc-391136A | 500 µg 1 mg | $540.00 $932.00 | ||
PACAP activates the PAC1 receptor, leading to increased cAMP levels. The resulting enhancement of the cAMP-PKA pathway, in which MIC1 is involved, leads to increased MIC1 activity. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine activates the D1-like receptor, involved in the cAMP-PKA pathway. This can lead to an increase in MIC1 activity by promoting cAMP levels and PKA activation. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine activates the H2 receptor, involved in the cAMP-PKA pathway. This can enhance MIC1 activity by promoting cAMP levels and PKA activation. | ||||||
Serotonin hydrochloride | 153-98-0 | sc-201146 sc-201146A | 100 mg 1 g | $118.00 $187.00 | 15 | |
Serotonin activates the 5-HT4, 5-HT6, and 5-HT7 receptors, involved in the cAMP-PKA pathway. This can enhance MIC1 activity by promoting cAMP levels and PKA activation. | ||||||