MIC1 Antibody (D-7): sc-390305

MIC1 Antibody (D-7) is a mouse monoclonal IgM antibody that detects MIC1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-MIC1 antibody (D-7) is available as the non-conjugated form. MIC1 protein, also known as C18orf8, is a 657 amino acid protein characterized by the presence of a single MIC1 domain and is encoded by a gene located on human chromosome 18, which harbors over 300 protein-coding genes and spans nearly 76 million bases. MIC1 (D-7) antibody recognizes a protein crucial for regulating immune responses and inflammation, where dysregulation has been implicated in various diseases, including cancer and metabolic disorders. MIC1 protein interacts with specific proteins such as TGF-beta, which is essential for mediating cellular responses to stress and inflammation, making these interactions vital for understanding disease progression and developing targeted therapies.

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MIC1 Antibody (D-7) References:

1. Characterisation of a 19-year-old 'long-term survivor' with Edwards syndrome.  |  Petek, E., et al. 2003. Genet Couns. 14: 239-44. PMID: 12872820
2. A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex.  |  Raghavan, SC., et al. 2004. Nature. 428: 88-93. PMID: 14999286
3. Chromosome 18 aberrations and epilepsy: a review.  |  Grosso, S., et al. 2005. Am J Med Genet A. 134A: 88-94. PMID: 15690352
4. Heterogeneity of mutations in the ferrochelatase gene in Italian patients with erythropoietic protoporphyria.  |  Aurizi, C., et al. 2007. Mol Genet Metab. 90: 402-7. PMID: 17196862
5. A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk.  |  Broderick, P., et al. 2007. Nat Genet. 39: 1315-7. PMID: 17934461
6. Hereditary hemorrhagic telangiectasia.  |  Kamal, AH. and Prakash, UB. 2007. Mayo Clin Proc. 82: 1364. PMID: 17976356
7. Elevated factor VIII in hereditary haemorrhagic telangiectasia (HHT): association with venous thromboembolism.  |  Shovlin, CL., et al. 2007. Thromb Haemost. 98: 1031-9. PMID: 18000608
8. Linkage of Niemann-Pick disease type C to human chromosome 18.  |  Carstea, ED., et al. 1993. Proc Natl Acad Sci U S A. 90: 2002-4. PMID: 8446622

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MIC1 Antibody (D-7) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-MIC1 Antibody (D-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MIC1 Antibody (D-7) Specifications

Alternate Product Name: MIC1

Product Clone Name: D-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 613-645

Epitope Target: MIC1

Epitope Species: human

Product Reactivity/Detection: MIC1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for MIC1 Antibody (D-7): P: Blocking Peptide