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MHC class II I E Inhibitors

MHC class II I-E inhibitors are a specific class of chemical compounds that interact with the Major Histocompatibility Complex (MHC) class II molecules, particularly focusing on the I-E subset, which is a variant found in certain species such as mice. The MHC class II molecules are integral to the immune system, particularly in antigen presentation, where they present processed peptide antigens to CD4+ T cells. The I-E molecules, like other MHC class II molecules, are composed of alpha and beta chains that form a peptide-binding groove, which is crucial for their role in the immune response. Inhibitors of the MHC class II I-E subset function by interfering with this antigen-presenting process, often by binding to the peptide-binding groove or by altering the conformation of the MHC molecule, thus preventing the binding or stable presentation of peptide antigens. The specific inhibition of MHC class II I-E molecules can be particularly relevant in studies focusing on immune regulation and the molecular mechanisms underlying antigen presentation. These inhibitors are often utilized in research to dissect the specific roles of different MHC class II molecules in immune responses, providing insight into the structural and functional aspects of these proteins. By selectively inhibiting the I-E variant, researchers can explore the nuances of antigen processing and presentation, as well as the differential roles of various MHC class II molecules in immune signaling pathways. The use of MHC class II I-E inhibitors allows for a more targeted investigation into the biochemistry of immune interactions, enabling a deeper understanding of how these molecules contribute to the broader immune system's functions, particularly in species where the I-E subset is expressed.

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Product Name	CAS #	Catalog #	QUANTITY	Price	Citations	RATING
Curcumin	458-37-7	sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E	1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg	$37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00	47	(1)
Curcumin may downregulate the expression of MHC class II I-E by obstructing the activation of NF-κB, which is crucial for the transcriptional initiation of MHC class II genes.
Resveratrol	501-36-0	sc-200808 sc-200808A sc-200808B	100 mg 500 mg 5 g	$80.00 $220.00 $460.00	64	(2)
Resveratrol might decrease MHC class II I-E surface levels by hindering the NF-κB pathway, which plays a significant role in the inflammatory response and subsequent expression of MHC class II genes.
Chloroquine	54-05-7	sc-507304	250 mg	$69.00	2	(0)
Chloroquine is capable of disrupting lysosomal acidification, which is essential for antigen processing, leading to a reduction in MHC class II I-E molecule expression on the cell surface.
Wogonin, S. baicalensis	632-85-9	sc-203313	10 mg	$200.00	8	(1)
Wogonin could downregulate MHC class II I-E expression by inhibiting the JAK/STAT signaling pathway, which is involved in the signal transduction necessary for the expression of these molecules.
Genistein	446-72-0	sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F	100 mg 500 mg 1 g 5 g 10 g 25 g 100 g	$45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00	46	(1)
Genistein can decrease the expression of MHC class II I-E by inhibiting specific tyrosine kinases, thereby disrupting the phosphorylation cascade essential for the activation of genes encoding MHC class II.
(−)-Epigallocatechin Gallate	989-51-5	sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E	10 mg 50 mg 100 mg 500 mg 1 g 10 g	$43.00 $73.00 $126.00 $243.00 $530.00 $1259.00	11	(1)
Epigallocatechin Gallate has the potential to decrease MHC class II I-E expression by inhibiting the activation of NF-κB, which is involved in the transcription and coordination of immune responses.
BAY 11-7082	19542-67-7	sc-200615B sc-200615 sc-200615A	5 mg 10 mg 50 mg	$62.00 $85.00 $356.00	155	(1)
Bay 11-7082 might lead to a decrease in MHC class II I-E expression by irreversibly inhibiting the phosphorylation of IκBα, thereby preventing NF-κB from translocating to the nucleus and activating MHC class II genes.
Apigenin	520-36-5	sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F	5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg	$33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00	22	(1)
Apigenin has the potential to downregulate the expression of MHC class II I-E by interfering with the NF-κB and PI3K/Akt signaling pathways, which are crucial for the expression of MHC class II molecules.
Andrographolide	5508-58-7	sc-205594 sc-205594A	50 mg 100 mg	$15.00 $40.00	7	(1)
Andrographolide may inhibit the nuclear translocation of NF-κB, which is essential for the initiation of MHC class II I-E gene transcription, thus leading to reduced expression.
Dexamethasone	50-02-2	sc-29059 sc-29059B sc-29059A	100 mg 1 g 5 g	$91.00 $139.00 $374.00	36	(1)
Dexamethasone can reduce the expression of MHC class II I-E by activating glucocorticoid receptors, which can then translocate to the nucleus and interfere with the transcription factors involved in MHC class II gene expression.

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MHC class II I E Inhibitors

Curcumin

Resveratrol

Chloroquine

Wogonin, S. baicalensis

Genistein

(−)-Epigallocatechin Gallate

BAY 11-7082

Apigenin

Andrographolide

Dexamethasone