mGluR-6 Activators
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L(+)-2-Amino-4-phosphonobutanoic acid (L-AP4) | 23052-81-5 | sc-200432 | 5 mg | $94.00 | 1 | |
L(+)-2-Amino-4-phosphonobutanoic acid (L-AP4) acts as a potent agonist for the mGluR-6 receptor, exhibiting a high affinity for its binding site. This compound uniquely stabilizes the receptor in an active conformation, enhancing its signaling efficacy. L-AP4's molecular structure allows for specific electrostatic interactions with key amino acid residues, influencing receptor activation and downstream neuronal pathways. Its distinct kinetic profile promotes rapid receptor engagement, contributing to its functional specificity. | ||||||
(RS)-PPG | 120667-15-4 | sc-202797 | 5 mg | $71.00 | ||
(RS)-PPG serves as a selective modulator of the mGluR-6 receptor, characterized by its ability to induce conformational changes that facilitate receptor activation. This compound engages in unique hydrogen bonding and hydrophobic interactions with critical binding sites, enhancing receptor sensitivity to endogenous ligands. Its distinct reaction kinetics allow for a nuanced regulation of signaling pathways, influencing synaptic plasticity and neuronal communication. The compound's stereochemistry plays a pivotal role in its interaction dynamics, further distinguishing its functional profile. | ||||||
trans-(1S,3R)-ACPD | 111900-32-4 | sc-391145 | 5 mg | $197.00 | ||
Trans-(1S,3R)-ACPD acts as a potent agonist for the mGluR-6 receptor, exhibiting a unique ability to stabilize receptor conformations that promote downstream signaling. Its specific stereochemistry enhances binding affinity through tailored electrostatic interactions and van der Waals forces, optimizing receptor activation. The compound's kinetic profile reveals a rapid onset of action, allowing for precise modulation of intracellular calcium levels and synaptic transmission, thereby influencing neural circuit dynamics. | ||||||
L-γ-Carboxyglutamic acid | 53861-57-7 | sc-295277 sc-295277A | 10 mg 50 mg | $402.00 $1047.00 | ||
L-γ-Carboxyglutamic acid serves as a selective modulator of the mGluR-6 receptor, engaging in unique hydrogen bonding and ionic interactions that facilitate receptor activation. Its structural features promote distinct conformational changes, enhancing signal transduction pathways. The compound exhibits a notable influence on intracellular signaling cascades, contributing to the regulation of neurotransmitter release and synaptic plasticity, thereby shaping neuronal communication and network behavior. | ||||||
LY 354740 | 176199-48-7 | sc-204064 sc-204064A | 10 mg 50 mg | $266.00 $886.00 | 2 | |
LY354740 is a potent group II metabotropic glutamate receptor agonist and can indirectly enhance mGluR-6 activity through cross-activation within the group. | ||||||
(S)-3,5-DHPG | 162870-29-3 | sc-204256 sc-204256A | 5 mg 10 mg | $210.00 $353.00 | 2 | |
(S)-3,5-DHPG is a selective group I mGlu receptor agonist that can enhance mGluR-6 activity by modulating glutamate availability and receptor cross-talk. | ||||||
Cyclothiazide | 2259-96-3 | sc-202560 sc-202560A | 10 mg 50 mg | $107.00 $227.00 | 3 | |
Cyclothiazide inhibits desensitization of AMPA receptors and may indirectly promote mGluR-6 signaling by increasing synaptic glutamate in the retinal pathway. | ||||||
CPCCOEt | 179067-99-3 | sc-200481 sc-200481A | 10 mg 50 mg | $141.00 $599.00 | 1 | |
CPCCOEt is an mGluR-1 antagonist, but through receptor crosstalk mechanisms, can potentially enhance mGluR-6 activity in complex glutamate signaling networks. | ||||||