(RS)-PPG CAS: 120667-15-4
MF: C8H10NO5P
MW: 231.1
A potent and selective group III mGluR agonist.

(RS)-PPG (CAS 120667-15-4)

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Alternate Names: (RS)-Phosphonophenylglycine
Application: (RS)-PPG is a potent and selective group III mGluR agonist
CAS Number: 120667-15-4
Purity: ≥95%
Molecular Weight: 231.1
Molecular Formula: C8H10NO5P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

(RS)-PPG is a potent and selective group III mGluR (mGluR-4, mGluR-6, mGluR-7 and mGluR-8a) agonist, with a 25-fold specificity towards the mGluR-8a (hmGluR-8 receptor).


References

1. Bigge, C.F., et al. 1989. J. Med. Chem. 32: 1580-1590. PMID: 2544728
2. Schoepp, D.D., et al. 1999. Neuropharmacology. 38: 1431-1476. PMID: 10530808

Physical State :
Solid
Solubility :
Soluble in 1eq. NaOH (100 mM), and DMSO (2 mg/ml).
Storage :
Store at 4° C
Melting Point :
300° C
Boiling Point :
515.54° C at 760 mmHg (Predicted)
Density :
1.62 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
Metabotropic glutamate receptor 8 agonist activity against forskolin stimulated c-AMP formation: EC5050 = 0.21 µM (rat nonneuronal cells); Inhibition of forskolin stimulated cAMP accumulation: EC5050 = 3.2 µM (CHO cells expressing hmGluR4a); Metabotropic glutamate receptor 6 agonist activity to influence forskolin stimulated c-AMP formation: EC5050 = 4.7 µM (rat nonneuronal cells); Agonistic activity at Metabotropic glutamate receptor 4 expressed in mammalian cells: EC5050 = 4.7 µM; Metabotropic glutamate receptor 4 agonist activity to influence forskolin stimulated c-AMP formation: EC5050 = 5.2 µM (rat nonneuronal cells)
Ki Data :
mGLuR-8a: Ki= 0.21 µM (human); mGluR-6: Ki= 4.7 µM (human); mGluR-4: Ki= 5.2 µM (human)
pK Values :
pKa: 1.62 (Predicted), pKb: 10.2 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
4545574
MDL Number :
MFCD02262122
SMILES :
C1=CC(=CC=C1C(C(=O)O)N)P(=O)(O)O

Download SDS (MSDS)

Certificate of Analysis

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