mGluR-6 Antibody (1A11): sc-517076

mGluR-6 Antibody (1A11) is a mouse monoclonal IgG1 kappa light chain antibody that detects mGluR-6 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-mGluR-6 antibody (1A11) is available as a non-conjugated format. mGluR-6, a member of the metabotropic glutamate receptor family, plays a crucial role in the visual system by mediating synaptic transmission from rod and cone photoreceptors to bipolar cells. mGluR-6 is predominantly located in the synapses of bipolar cell dendrites, where mGluR-6 is essential for the processing of visual signals. mGluR-6 function is vital for normal visual perception, as mGluR-6 helps to modulate the flow of information from photoreceptors to inner retinal neurons, thereby influencing visual acuity and contrast sensitivity. Dysregulation of mGluR-6 has been implicated in various retinal disorders, making mGluR-6 a significant target for research in vision-related pathologies.

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mGluR-6 Antibody (1A11) References:

1. Night blindness and abnormal cone electroretinogram ON responses in patients with mutations in the GRM6 gene encoding mGluR6.  |  Dryja, TP., et al. 2005. Proc Natl Acad Sci U S A. 102: 4884-9. PMID: 15781871
2. Agonists and antagonists for group III metabotropic glutamate receptors 6, 7 and 8.  |  Yang, ZQ. 2005. Curr Top Med Chem. 5: 913-8. PMID: 16178735
3. Mutations in GRM6 cause autosomal recessive congenital stationary night blindness with a distinctive scotopic 15-Hz flicker electroretinogram.  |  Zeitz, C., et al. 2005. Invest Ophthalmol Vis Sci. 46: 4328-35. PMID: 16249515
4. Congenital stationary night blindness associated with mutations in GRM6 encoding glutamate receptor MGluR6.  |  O'Connor, E., et al. 2006. Br J Ophthalmol. 90: 653-4. PMID: 16622103
5. The whole nucleotide sequence and chromosomal localization of the gene for human metabotropic glutamate receptor subtype 6.  |  Hashimoto, T., et al. 1997. Eur J Neurosci. 9: 1226-35. PMID: 9215706

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-mGluR-6 Antibody (1A11) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-mGluR-6 Antibody (1A11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

mGluR-6 Antibody (1A11) Specifications

Alternate Product Name: mGluR-6

Product Clone Name: 1A11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 477-566

Epitope Target: mGluR-6

Epitope Species: human

Product Reactivity/Detection: mGluR-6

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for mGluR-6 Antibody (1A11): N/A