Molecular structure of CPCCOEt, CAS Number: 179067-99-3
CPCCOEt (CAS 179067-99-3)
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Alternate Names:
Ethyl-7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester
Application:
CPCCOEt is a mGluR-1 antagonist
CAS Number:
179067-99-3
Purity:
98%
Molecular Weight:
247.2
Molecular Formula:
C13H13NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CPCCOEt is a reversible and non-competitive antagonist of mGluR-1 (type 1a mGluR-1 ametabotropic glutamate receptor) activation. Inhibition of the mGluR-1(mGluR-1metabotropic glutamate receptor 1) signal does not affect glutamate binding (IC50=6.5 μM). Studies propose that CPCCOEt inhibits mGluR-1 by preventing the interaction between the agonist-bound extracellular domain and the transmembrane domain. Research shows that CPCCOEt has the ability to improve the tumoricidal effects of cytostatic drugs and that it enhances the climbing fire response in Purkinje neurons, independent of glutamate receptors.
CPCCOEt (CAS 179067-99-3) References
- CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding. | Litschig, S., et al. 1999. Mol Pharmacol. 55: 453-61. PMID: 10051528
- Dendritic release of glutamate suppresses synaptic inhibition of pyramidal neurons in rat neocortex. | Zilberter, Y. 2000. J Physiol. 528: 489-96. PMID: 11060126
- Pharmacology of the metabotropic glutamate receptor mediated current at the climbing fiber to Purkinje cell synapse. | Zhu, L., et al. 2005. Prog Brain Res. 148: 299-306. PMID: 15661198
- mGLuRs, AChE-Is and PDE4. | Worker, C. 1999. IDrugs. 2: 853-5. PMID: 16121293
- The mGlu1 antagonist CPCCOEt enhances the climbing fibre response in Purkinje neurones independently of glutamate receptors. | Fukunaga, I., et al. 2007. Neuropharmacology. 52: 450-8. PMID: 17045308
- The non-competitive metabotropic glutamate receptor-1 antagonist CPCCOEt inhibits the in vitro growth of human melanoma. | Haas, HS., et al. 2007. Oncol Rep. 17: 1399-404. PMID: 17487397
- Modulation of intracellular calcium mobilization and GABAergic currents through subtype-specific metabotropic glutamate receptors in neonatal rat hippocampus. | Taketo, M. and Matsuda, H. 2010. Brain Res Bull. 81: 73-80. PMID: 19628026
- Activation of group I metabotropic glutamate receptors leads to brain-derived neurotrophic factor expression in rat C6 cells. | Viwatpinyo, K. and Chongthammakun, S. 2009. Neurosci Lett. 467: 127-30. PMID: 19822193
- Homer1a signaling in the amygdala counteracts pain-related synaptic plasticity, mGluR1 function and pain behaviors. | Tappe-Theodor, A., et al. 2011. Mol Pain. 7: 38. PMID: 21595930
- Postsynaptic mGluR mediated excitation of neurons in midbrain periaqueductal grey. | Wilson-Poe, AR., et al. 2013. Neuropharmacology. 66: 348-54. PMID: 22771462
- Local group I mGluR antagonists reduce TMJ-evoked activity of trigeminal subnucleus caudalis neurons in female rats. | Tashiro, A., et al. 2015. Neuroscience. 299: 125-33. PMID: 25934040
- Glutamate Attenuates the Survival Property of IGFR through NR2B Containing N-Methyl-D-aspartate Receptors in Cortical Neurons. | Zhao, X., et al. 2020. Oxid Med Cell Longev. 2020: 5173184. PMID: 32849999
- Reversible and non-competitive antagonist profile of CPCCOEt at the human type 1alpha metabotropic glutamate receptor. | Hermans, E., et al. 1998. Neuropharmacology. 37: 1645-7. PMID: 9886688
Inhibitor of:
mGluR.Activator of:
mGluR-6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CPCCOEt, 10 mg | sc-200481 | 10 mg | $141.00 | |||
CPCCOEt, 50 mg | sc-200481A | 50 mg | $599.00 |