MFG-E8 Inhibitors
MFG-E8 inhibitors belong to a specialized chemical class designed to target a specific protein known as Milk Fat Globule-EGF Factor 8 (MFG-E8). MFG-E8 is a glycoprotein that plays a crucial role in various biological processes, particularly in the clearance of apoptotic cells, a process called efferocytosis. This protein acts as a bridge between apoptotic cells and phagocytes, such as macrophages, facilitating the efficient removal of dying or dead cells from tissues. By inhibiting MFG-E8, these compounds interfere with the efferocytosis process, which has implications in various physiological and pathological conditions.
MFG-E8 inhibitors typically act by binding to specific regions of the MFG-E8 protein, disrupting its ability to interact with phagocytes and apoptotic cells. This disruption can result in impaired clearance of apoptotic cells and debris, leading to an accumulation of cellular waste and inflammation. Consequently, the development of MFG-E8 inhibitors has generated interest in the scientific community, as they offer a promising avenue for understanding and modulating the immune response and tissue homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is known to exhibit anti-inflammatory properties, and its interaction with various signaling pathways may lead to the downregulation of MFG-E8 expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol found in grapes and red wine, has been shown to modulate various cellular processes, potentially resulting in decreased MFG-E8 levels. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid with known anti-inflammatory effects. It may influence the expression of MFG-E8 by modulating related signaling pathways. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Found in cruciferous vegetables, sulforaphane has demonstrated potential in modulating inflammation and may impact MFG-E8 expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a major component of green tea, has anti-inflammatory properties and may play a role in the regulation of MFG-E8 expression. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D plays a vital role in immune function, and its adequate levels are associated with balanced inflammatory responses, potentially affecting MFG-E8 expression. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc is an essential trace element that is crucial for immune function. Its proper regulation may have an impact on MFG-E8 levels. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $62.00 | 1 | |
Selenium, an essential mineral, is involved in various cellular processes, including the modulation of inflammatory responses, which could influence MFG-E8 expression. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Aspirin is a non-steroidal anti-inflammatory compound (NSAID) that may modulate various signaling pathways, potentially impacting MFG-E8 expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is known for its immunosuppressive properties and may affect MFG-E8 expression through the modulation of cellular signaling. | ||||||