Mex67 Activators
The term Mex67 Activators would denote a class of chemicals aimed at modulating the activity of the Mex67 protein. Mex67, in the context of yeast like Saccharomyces cerevisiae, is a well-studied nuclear export receptor that plays a pivotal role in the mRNA export from the nucleus to the cytoplasm. It forms a heterodimer with Mtr2 and is essential for the binding of mRNA-protein complexes (mRNPs) and their subsequent translocation through the nuclear pore complex. Activators of Mex67 would therefore be molecules that enhance its RNA-binding affinity, its interaction with Mtr2, or its overall stability and function in the mRNA export pathway. Such activators might bind to specific domains of Mex67, inducing a conformational change that promotes its function, or they may stabilize the Mex67-Mtr2 complex, thereby facilitating a more efficient nuclear export process.
The study of Mex67 activators would involve a comprehensive approach to elucidate their mechanism of action at the molecular and cellular levels. Researchers would employ various in vitro assays to monitor the binding efficiency of Mex67 to mRNA or to the Mtr2 partner in the presence of these activators. These assays could include techniques such as electrophoretic mobility shift assays (EMSAs) for assessing RNA binding or co-immunoprecipitation to study Mex67-Mtr2 complex formation. Furthermore, in vivo studies using fluorescently labeled mRNA would allow visualization of the nuclear export in real-time, providing insight into how these activators influence Mex67-mediated export kinetics. Advanced structural analysis techniques, such as cryo-electron microscopy or X-ray crystallography, could be used to determine the binding sites of activators on Mex67 and to visualize how such binding affects the Mex67-Mtr2-mRNA complex. Through these studies, a detailed understanding of Mex67 function in mRNA export and how it can be modulated by small molecules would be gained, contributing to the cell biology field's knowledge of nuclear-cytoplasmic transport mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
A histone deacetylase inhibitor that could lead to changes in chromatin structure and gene expression, potentially affecting Mex67 expression. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $66.00 $153.00 | 16 | |
Affects protein folding and can induce a heat shock response, which may enhance the expression of various proteins, including Mex67, as part of the stress response. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $106.00 $765.00 | 3 | |
Can induce oxidative stress and a heat shock response, potentially leading to increased expression of proteins involved in stress responses, which may include Mex67. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
As a steroid hormone, it can interact with the estrogen receptor and may influence gene expression patterns, possibly affecting Mex67 expression indirectly. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Induces endoplasmic reticulum stress and the unfolded protein response, which could lead to changes in gene expression and potentially increase Mex67 expression. | ||||||
Vitamin K3 | 58-27-5 | sc-205990B sc-205990 sc-205990A sc-205990C sc-205990D | 5 g 10 g 25 g 100 g 500 g | $25.00 $35.00 $46.00 $133.00 $446.00 | 3 | |
Generates oxidative stress, which could lead to the activation of stress response pathways and potentially upregulate Mex67 expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Inhibits the mTOR pathway, which is involved in the regulation of many cellular processes, including protein synthesis and stress responses, and could influence Mex67 expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
By affecting GSK-3 activity and other signaling pathways, lithium chloride could influence gene expression, potentially affecting Mex67 levels. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Antipsychotic that can affect a variety of cellular signaling pathways and may indirectly influence gene expression, including that of Mex67. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Disrupts transport between the endoplasmic reticulum and Golgi apparatus, leading to stress responses that could affect Mex67 expression. | ||||||