METTL4 Activators

METTL4 is a protein encoded by the gene METTL4 in humans. It is known to be a part of the family of methyltransferases, which are enzymes that catalyze the transfer of a methyl group from a donor molecule, like S-adenosylmethionine (SAM), to various substrates including proteins, nucleic acids, and other small molecules. Methyltransferases play crucial roles in various biological processes, including but not limited to gene regulation, protein function, and signal transduction.

The specific functions of METTL4 are still under investigation, but like other methyltransferases, it is presumed to be involved in epigenetic regulation or modification of RNA or DNA. Epigenetic modifications are chemical changes to the genome that do not alter the nucleotide sequence but can affect gene expression and are heritable during cell division. These modifications include methylation of DNA and various forms of RNA methylation, such as N6-methyladenosine (m6A) modification, which is the most common and well-studied methylation modification in RNA.The exact substrates and the physiological role of METTL4 are areas of active research. Understanding the function of METTL4 is important because RNA modifications like m6A influence RNA stability, splicing, localization, and translation, thus affecting many aspects of cellular function. Aberrant methylation can lead to a variety of human diseases, including cancers and neurological disorders.