METTL2B Inhibitors
METTL2B inhibitors belong to a class of compounds designed to target the METTL2B enzyme, a member of the methyltransferase family. METTL2B, also known as methyltransferase-like 2B, plays a crucial role in the process of RNA modification by catalyzing the transfer of methyl groups to specific RNA molecules. This enzymatic activity is part of the broader field of epitranscriptomics, focusing on modifications occurring on RNA molecules that impact various cellular processes. METTL2B, specifically, is involved in the methylation of adenosine residues in RNA, contributing to the dynamic regulation of gene expression.
The development of METTL2B inhibitors represents a significant advancement in the exploration of epitranscriptomic modifications as potential targets for modulation. By selectively inhibiting METTL2B, researchers aim to decipher the intricate roles of RNA methylation in cellular functions and unveil potential implications in disease processes. These inhibitors are designed to interact with the catalytic site of METTL2B, disrupting its methyltransferase activity and providing researchers with a valuable tool to investigate the functional consequences of inhibiting this specific RNA modification. The exploration of METTL2B inhibitors opens new avenues for understanding the molecular mechanisms underlying RNA modifications and their impact on cellular physiology, contributing to the broader landscape of epitranscriptomic research.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1-Aminocyclopentanecarboxylic acid | 52-52-8 | sc-202392 | 1 g | $23.00 | ||
Cycloleucine is an inhibitor of S-adenosylmethionine-dependent methyltransferases by acting as an antagonist of the methionine adenosyltransferase enzyme. This leads to a decrease in SAM production, thereby indirectly decreasing METTL2B activity as it has less substrate for methylation. | ||||||
Adenosine, periodate oxidized | 34240-05-6 | sc-214510 sc-214510A | 25 mg 100 mg | $119.00 $364.00 | ||
AdOx inhibits S-adenosylhomocysteine hydrolase, leading to an accumulation of S-adenosylhomocysteine (SAH), which is a potent inhibitor of SAM-dependent methyltransferases including METTL2B. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Decitabine is a cytidine analog that, when incorporated into DNA, can trap DNA methyltransferases, potentially also affecting proteins like METTL2B that share functional domains with these enzymes. | ||||||
Hydralazine-15N4 Hydrochloride | 304-20-1 (unlabeled) | sc-490605 | 1 mg | $480.00 | ||
Hydralazine is known to induce demethylation of DNA by inhibiting DNA methyltransferases. As a result, it could also potentially impact the activity of METTL2B by altering the methylation landscape it acts upon. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108 is a non-nucleoside DNA methyltransferase inhibitor. Although its primary target is DNA methyltransferases, it may indirectly affect METTL2B by altering the methylation patterns and substrate availability. | ||||||
Sinefungin | 58944-73-3 | sc-203263 sc-203263B sc-203263C sc-203263A | 1 mg 100 mg 1 g 10 mg | $271.00 $5202.00 $40368.00 $704.00 | 4 | |
Sinefungin is a natural nucleoside that acts as a universal inhibitor of S-adenosylmethionine-dependent methyltransferases, thus it could inhibit METTL2B by competing with SAM. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $37.00 $112.00 $408.00 | ||
BIX-01294 is a histone methyltransferase inhibitor that could indirectly affect METTL2B by disrupting methylation-dependent signaling pathways related to the protein's function. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $126.00 | 5 | |
Chaetocin is a specific inhibitor of histone methyltransferases. Its action on these enzymes could influence cellular methylation patterns, potentially impacting METTL2B's activity. | ||||||
5′-Deoxy-5′-methylthioadenosine | 2457-80-9 | sc-202427 | 50 mg | $122.00 | 1 | |
This compound is a byproduct of polyamine synthesis that can inhibit methyltransferase activity by acting as a competitive inhibitor with respect to the methyl donor SAM, thereby affecting METTL2B's function. | ||||||
3-Deazaneplanocin, HCl salt | 120964-45-6 | sc-351856 sc-351856A sc-351856B | 1 mg 5 mg 10 mg | $256.00 $612.00 $936.00 | 2 | |
DZNep is an inhibitor of S-adenosylhomocysteine hydrolase, leading to increased levels of SAH which inhibits SAM-dependent methyltransferases, including METTL2B. | ||||||