METTL2B Activators
METTL2B Activators are chemical compounds that indirectly influence the methylation activity of METTL2B by modulating the availability of substrates or co-factors that are essential for its enzymatic function. For instance, S-Adenosylmethionine, the primary methyl donor for METTL2B, directly enhances its methylation capability by providing the necessary methyl groups. The availability of S-Adenosylmethionine can be increased through the inhibition of SAH Hydrolase by DZ2002, which ultimately leads to higher substrate levels for METTL2B. Additionally, compounds like (R)-Pantetheine, Nicotinamide Adenine Dinucleotide (NAD+), Folic Acid, and Vitamin B12 play pivotal roles in the methionine cycle, which is intricately linkedto the production of S-Adenosylmethionine, thereby indirectly augmenting METTL2B activity. Moreover, Betaine contributes to this cycle by donating methyl groups to homocysteine, thus enhancing the synthesis of methionine and its conversion to the active methyl donor S-Adenosylmethionine.
Essential trace elements such as Zinc and Magnesium serve as cofactors for enzymes in the methylation pathway, including those that synthesize S-Adenosylmethionine, indirectly facilitating the methylation process carried out by METTL2B. Choline, through its oxidation to betaine, and Riboflavin, as a precursor to the FAD cofactor, also contribute to the methylation cycle, supporting the production of S-Adenosylmethionine. Pyridoxal Phosphate (Vitamin B6) is yet another cofactor that impacts the cycle by aiding enzymes like cystathionine beta-synthase, ultimately influencing the synthesis of methionine and the availability of the methyl donor for METTL2B's function. Collectively, these activators create a biochemical milieu that bolsters the methylation capacity of METTL2B, thereby enhancing its activity without directly binding to the enzyme or upregulating its expression.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
S-Adenosylmethionine is a common cosubstrate involved in methyl group transfers, which is critical for the methylation activity of METTL2B on target RNA molecules. By providing the methyl group, it directly enhances the methylation function of METTL2B. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ is a cofactor for various dehydrogenase reactions, which can influence the methionine cycle and indirectly enhance the production of S-Adenosylmethionine, thus supporting METTL2B activity. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $73.00 | 2 | |
Folic Acid is essential for the methionine cycle and indirectly supports the biosynthesis of S-Adenosylmethionine, which is necessary for METTL2B methyltransferase activity. | ||||||
Vitamin B12 | 68-19-9 | sc-296695 sc-296695A sc-296695B sc-296695C sc-296695D sc-296695E | 100 mg 1 g 5 g 25 g 100 g 1 kg | $60.00 $90.00 $325.00 $1155.00 $3851.00 $10056.00 | 2 | |
Vitamin B12 is crucial for the function of methionine synthase, an enzyme in the methionine cycle that assists in the regeneration of methionine and the subsequent production of S-Adenosylmethionine, indirectly enhancing METTL2B activity. | ||||||
Betaine | 107-43-7 | sc-214595 sc-214595A sc-214595B sc-214595C sc-214595D sc-214595E | 50 g 100 g 250 g 1 kg 2.5 kg 5 kg | $31.00 $41.00 $56.00 $163.00 $337.00 $592.00 | 2 | |
Betaine participates in the methionine cycle by donating a methyl group to homocysteine to form methionine, which is a precursor to S-Adenosylmethionine, indirectly supporting METTL2B's methylation function. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc acts as a cofactor for many enzymes including methionine synthase, thereby potentially increasing the availability of methionine for the production of S-Adenosylmethionine and indirectly enhancing METTL2B activity. | ||||||
Choline chloride | 67-48-1 | sc-207430 sc-207430A sc-207430B | 10 mg 5 g 50 g | $33.00 $37.00 $52.00 | 1 | |
Choline can be oxidized to betaine, which in turn participates in the methionine cycle to enhance the synthesis of methionine and subsequently S-Adenosylmethionine, indirectly supporting METTL2B methyltransferase activity. | ||||||
Riboflavin | 83-88-5 | sc-205906 sc-205906A sc-205906B | 25 g 100 g 1 kg | $41.00 $112.00 $525.00 | 3 | |
Riboflavin is a precursor of FAD, a cofactor for methylenetetrahydrofolate reductase (MTHFR) in the methionine cycle, indirectly enhancing the production of S-Adenosylmethionine and thereby METTL2B activity. | ||||||
Pyridoxal-5-phosphate | 54-47-7 | sc-205825 | 5 g | $104.00 | ||
Pyridoxal Phosphate is a cofactor for enzymes in the methionine cycle such as cystathionine beta-synthase, indirectly influencing the synthesis of methionine and the availability of S-Adenosylmethionine for METTL2B's methyltransferase function. | ||||||