METTL14 Activators
METTL14 Activators belong to a distinctive class of chemical compounds that modulate the activity of the METTL14 enzyme within the context of cellular processes. METTL14 is a crucial component of the m6A methyltransferase complex, playing a pivotal role in the dynamic regulation of RNA methylation, specifically the N6-methyladenosine (m6A) modification. This class of activators is characterized by their ability to enhance the catalytic function of METTL14, promoting the efficient methylation of adenosine residues in RNA molecules. The activation of METTL14 by these compounds is thought to occur through a variety of mechanisms, including conformational changes that facilitate substrate binding and enzymatic activity.
Structurally diverse, METTL14 Activators interact with specific binding sites on the METTL14 enzyme, inducing a conformational change that optimizes its catalytic efficiency. These compounds may act allosterically or directly at the active site of METTL14, influencing its substrate recognition and binding kinetics. The modulation of METTL14 activity by these activators holds significance in cellular processes where m6A methylation is crucial, such as mRNA stability, splicing, and translation. Understanding the precise molecular mechanisms underlying METTL14 activation by this class of compounds opens avenues for elucidating the intricate regulatory networks governing RNA modifications and provides insights into the broader landscape of epitranscriptomics, contributing to the expanding field of RNA biology.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Meclofenamic Acid | 644-62-2 | sc-211780 | 5 mg | $402.00 | ||
Meclofenamic acid is known to be an inhibitor of the FTO protein, which demethylates m6A RNA, the product of METTL14 activity. Inhibition of FTO can result in the accumulation of m6A-modified RNA, indirectly enhancing the apparent activity of METTL14 by preventing the removal of the modifications it adds. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
This compound is a DNA methyltransferase inhibitor that can lead to alterations in the epigenomic landscape. These changes may upregulate certain RNA transcripts that are substrates for METTL14, thereby indirectly enhancing the functional activity of METTL14 through increased substrate availability. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $63.00 $110.00 $214.00 | 1 | |
Ribavirin, a nucleoside analog, can incorporate into RNA and potentially alter RNA methylation patterns. This might indirectly affect the activity of METTL14 by changing the substrate specificity or by enhancing the recognition of RNA substrates by METTL14 for methylation. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide is a form of vitamin B3 and an inhibitor of SIRT1, a deacetylase. By inhibiting SIRT1, it can lead to hyperacetylation of proteins involved in RNA processing, potentially affecting the binding of METTL14 to its RNA substrates and enhancing its activity indirectly through changes in the RNA-protein interaction landscape. | ||||||
Homocysteine | 6027-13-0 | sc-507315 | 250 mg | $195.00 | ||
SAH is a product inhibitor of methyltransferase reactions, which accumulates when methyltransferase activity is high. By providing feedback inhibition, SAH can indirectly reflect the enhanced activity of METTL14 as it is indicative of increased methylation turnover, suggesting that the functional activity of METTL14 is high when SAH levels rise. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108 is a DNA methyltransferase inhibitor that can alter gene expression patterns. Such changes in gene expression may indirectly increase the production of RNAs that are substrates for METTL14, enhancing its functional activity by providing more targets for methylation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a catechin found in green tea, has been shown to have various effects on cellular methylation pathways. Although not directly linked to METTL14, its influence on the cellular methyl pool can indirectly affect the activity of METTL14 by altering substrate availability and methylation dynamics. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
Entinostat is a histone deacetylase inhibitor that can modify chromatin structure and gene expression. Altered expression of genes may lead to increased RNA substrates for METTL14, thereby indirectly enhancing its activity by providing more methylation targets. | ||||||