METT10D Inhibitors
METT10D inhibitors are compounds primarily aimed at influencing RNA methylation and cellular methylation processes, rather than specifically targeting METT10D. These compounds work by various mechanisms, with many focusing on the broader methylation dynamics in cells. For instance, chemicals like 3-Deazaneplanocin A and Adenosine Dialdehyde target SAH hydrolase, potentially reducing substrate availability for RNA methyltransferases, thereby impacting RNA modifications. Others, like Meclofenamic Acid, directly inhibit enzymes responsible for m6A RNA demethylation, such as FTO, thus affecting the m6A RNA modification balance.
Given the crucial role of methylation in numerous cellular processes, these compounds can exert influence on RNA metabolism and processing, indirectly affecting METT10D's function. Molecules like 5-Azacytidine, RG108, and Decitabine act as DNA methyltransferase inhibitors, potentially influencing the overall cellular methylation landscape. Such alterations in the methylation state can potentially influence METT10D's m6A RNA modification activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine, periodate oxidized | 34240-05-6 | sc-214510 sc-214510A | 25 mg 100 mg | $117.00 $357.00 | ||
By inhibiting SAH hydrolase, it can raise intracellular SAH levels, potentially reducing METT10D's RNA methylation activity through competition with SAM. | ||||||
Meclofenamic Acid | 644-62-2 | sc-211780 | 5 mg | $394.00 | ||
Inhibits FTO, an m6A RNA demethylase. By suppressing the demethylation process, it indirectly promotes m6A RNA methylation, potentially compensating for METT10D's activity. | ||||||
5′-Deoxy-5′-methylthioadenosine | 2457-80-9 | sc-202427 | 50 mg | $120.00 | 1 | |
Interferes with the methionine cycle, which can lead to reduced availability of SAM. Less SAM may limit METT10D's RNA methylation capability. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methyltransferase inhibitor, it alters the overall methylation state. Changes in DNA methylation can alter gene expression profiles, potentially affecting proteins that collaborate or interact with METT10D. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
Changes cellular methylation dynamics by inhibiting DNA methyltransferases. Altered methylation can influence RNA processing proteins, potentially affecting METT10D's RNA targets or interaction partners. | ||||||
Hydralazine-15N4 Hydrochloride | 304-20-1 (unlabeled) | sc-490605 | 1 mg | $480.00 | ||
By demethylating DNA, it might affect expression of RNA processing machinery or METT10D's functional partners, potentially altering METT10D's role. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Inhibits DNA methyltransferase, which can change the expression profile of certain genes. This may indirectly modify METT10D's RNA targets or its interaction network. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Its role as a DNA methyltransferase inhibitor can modify gene expression profiles, which may influence METT10D's functional landscape within the cell. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Inhibits DNA methyltransferase activity, which can change the expression of genes related to RNA processing or methylation, thereby indirectly affecting METT10D's function. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $126.00 $278.00 $984.00 | 3 | |
By acting as a DNA demethylating agent, it may impact the expression of genes in METT10D's functional pathway, potentially modulating its activity or its cellular context. | ||||||