Meteorin Inhibitors
Chemical inhibitors of Meteorin can target various signaling pathways that are involved in the functional activities of the protein, such as neuronal growth, differentiation, and angiogenesis. SB203580, for instance, inhibits p38 MAP kinase, a key player in inflammatory responses and differentiation processes. By obstructing this pathway, SB203580 can disrupt the downstream cellular functions that Meteorin typically promotes. Similarly, the MEK inhibitors PD98059, U0126, AZD6244 (Selumetinib), and SL327 act on the ERK pathway, which is another significant route for transmitting Meteorin's effects on neurogenesis. These inhibitors prevent the MEK-induced activation of ERK, thereby blocking the signaling cascade that may be crucial for Meteorin's role in cell differentiation and proliferation.
Further, the PI3K/Akt pathway inhibitors, LY294002 and Wortmannin, can impede the pathways that Meteorin may use to regulate cell survival and neurogenesis. By preventing PI3K activity, these inhibitors can disrupt the downstream effects mediated by Meteorin through the Akt pathway. Rapamycin, an mTOR pathway inhibitor, can also suppress the growth and proliferation signals facilitated by Meteorin, as mTOR is a central regulator of cellular metabolism and growth. Moreover, Y-27632 targets the RhoA/ROCK pathway, which is implicated in gliogenesis, a process that Meteorin can influence. The inhibition of ROCK by Y-27632 can thus curtail the Meteorin-associated signaling involved in glial cell development. Dorsomorphin (Compound C) not only hampers the AMPK pathway but also the BMP signaling, which can be a conduit for Meteorin's effects on glial lineage specification. BIX02189 specifically inhibits MEK5, thereby impeding the ERK5 pathway, another potential mediator of Meteorin's action in neuronal differentiation and survival.
SEE ALSO...
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAP kinase inhibitor. Meteorin is known to promote angiogenesis and neural development, processes that can involve the p38 MAPK pathway. By inhibiting p38 MAPK, SB203580 can inhibit the downstream effects on cellular functions that Meteorin would typically promote. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is an inhibitor of phosphoinositide 3-kinases (PI3K). Meteorin-induced signaling may engage the PI3K/Akt pathway to exert its effects on neuronal growth and differentiation. Inhibition of PI3K by LY294002 can therefore inhibit the signaling cascade that Meteorin utilizes to function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a MEK inhibitor that prevents the activation of the extracellular signal-regulated kinase (ERK) pathway. Meteorin can influence neuronal differentiation, potentially through the ERK pathway. Inhibiting MEK with PD98059 can inhibit the ERK pathway activation that Meteorin may promote. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). Meteorin may utilize the JNK pathway in its role in neurogenesis and anti-inflammatory responses. By inhibiting JNK, SP600125 can inhibit the functional effects of Meteorin in these contexts. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a selective inhibitor of both MEK1 and MEK2. Similar to PD98059, it prevents the activation of ERK. As Meteorin may act through pathways involving MEK/ERK signaling, U0126 can inhibit the functional influence of Meteorin on cells. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent PI3K inhibitor, similar to LY294002. It can inhibit the PI3K/Akt pathway, which Meteorin might utilize to exert its effects on cell survival and neurogenesis. Wortmannin can thus inhibit the functional activities of Meteorin mediated through this pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor. The mTOR pathway can be involved in the regulation of cell growth and proliferation, which Meteorin may affect. Inhibition of mTOR by Rapamycin can inhibit the cell growth and proliferation signals that Meteorin promotes. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a ROCK inhibitor. Meteorin has been shown to have effects on gliogenesis, a process that can involve RhoA/ROCK signaling. Inhibition of ROCK by Y-27632 can inhibit the RhoA/ROCK pathway and the functional aspects of Meteorin associated with this signaling. | ||||||
Selumetinib | 606143-52-6 | sc-364613 sc-364613A sc-364613B sc-364613C sc-364613D | 5 mg 10 mg 100 mg 500 mg 1 g | $29.00 $82.00 $420.00 $1897.00 $3021.00 | 5 | |
AZD6244, also known as Selumetinib, is a MEK1/2 inhibitor. By inhibiting MEK1/2, AZD6244 can inhibit the MEK/ERK pathway, thereby inhibiting the potential signaling cascades utilized by Meteorin in cellular differentiation and growth. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $96.00 $355.00 | 69 | |
Dorsomorphin is an inhibitor of BMP signaling and also known as Compound C, which inhibits AMPK. Meteorin can influence glial cell lineages possibly via BMP signaling pathways. Inhibition of this pathway by Dorsomorphin can inhibit the functional roles of Meteorin in glial differentiation. | ||||||