Meteorin Activators
Meteorin Activators are chemical compounds that specifically enhance the functional activity of Meteorin, a protein involved in the cAMP-PKA pathway. These activators mainly act by increasing the levels of cAMP, which is a crucial second messenger involved in multiple biological processes. For example, Epinephrine, Isoproterenol, PGE2, PACAP, GLP-1, VIP, Dopamine, Histamine, and Serotonin are all able to increase cAMP levels by activating specific receptors that are involved in the cAMP-PKA pathway that Meteorin is a part of. The increased cAMP levels can enhance the activity of PKA, leading to an increase in the functional activity of Meteorin.
In addition, some Meteorin Activators function by inhibiting the breakdown of cAMP, leading to increased levels of this second messenger in the cell. For instance, Rolipram and IBMX inhibit phosphodiesterase, an enzyme that degrades cAMP, leading to increased intracellular cAMP levels. Forskolin, on the other hand, directly stimulates adenylate cyclase, the enzyme responsible for the synthesis of cAMP from ATP. As the level of cAMP rises, the activation of PKA is enhanced and, consequently, the functional activity of Meteorin is increased.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine can activate the β-adrenoceptor, which is involved in the cAMP-PKA pathway. Meteorin is known to be involved in this pathway and its activity can be enhanced through the increased levels of cAMP, leading to greater PKA activation which then promotes the functional activity of Meteorin. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin can stimulate adenylate cyclase, leading to increased levels of cAMP. The elevated cAMP levels can enhance the activity of PKA, which is involved in the cAMP-PKA pathway that Meteorin is a part of, leading to an increase in the functional activity of Meteorin. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a β-adrenoceptor agonist that increases cAMP levels. The increase in cAMP can enhance the activity of PKA, thereby promoting the functional activity of Meteorin, which is involved in the cAMP-PKA pathway. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase-4, preventing the breakdown of cAMP. The resulting increase in cAMP levels can enhance the activity of PKA, which is involved in the cAMP-PKA pathway that Meteorin is a part of, leading to an increase in the functional activity of Meteorin. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterase, preventing the breakdown of cAMP. Increased cAMP levels can enhance the activity of PKA, which is involved in the cAMP-PKA pathway that Meteorin is a part of, leading to an increase in the functional activity of Meteorin. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 activates the EP2 receptor, which is involved in the cAMP-PKA pathway. This can enhance the activity of PKA, leading to an increase in the functional activity of Meteorin. | ||||||
PACAP(6-38) | 137061-48-4 | sc-391136 sc-391136A | 500 µg 1 mg | $540.00 $932.00 | ||
PACAP activates the PAC1 receptor, which can increase cAMP levels. The increased cAMP levels can enhance the activity of PKA, which is involved in the cAMP-PKA pathway that Meteorin is a part of, leading to increased functional activity of Meteorin. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine can activate the D1-like receptor, which is involved in the cAMP-PKA pathway. This can enhance the activity of PKA, leading to an increase in the functional activity of Meteorin. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine can activate the H2 receptor, which is involved in the cAMP-PKA pathway. This can enhance the activity of PKA, leading to an increase in the functional activity of Meteorin. | ||||||
Serotonin hydrochloride | 153-98-0 | sc-201146 sc-201146A | 100 mg 1 g | $118.00 $187.00 | 15 | |
Serotonin can activate the 5-HT4, 5-HT6, and 5-HT7 receptors, which are involved in the cAMP-PKA pathway. This can enhance the activity of PKA, leading to an increase in the functional activity of Meteorin. | ||||||