MerTK Activators
MerTK activators are a class of chemical compounds that specifically target and modulate the activity of the MerTK receptor tyrosine kinase. MerTK, short for Mer Tyrosine Kinase, is a member of the TAM family of receptor tyrosine kinases, which also includes Tyro3 and Axl. These receptors play essential roles in various cellular processes, particularly in the regulation of immune responses, tissue homeostasis, and the clearance of apoptotic cells. MerTK, in particular, is primarily associated with the phagocytosis of apoptotic cells and the regulation of inflammation. Activating MerTK can have significant implications for cellular and immune responses.
Chemically, MerTK activators are designed to bind to and activate MerTK, triggering a series of intracellular signaling events. These activators often work by mimicking the binding of MerTK's natural ligands, such as Gas6 and Protein S, to the receptor's extracellular domain. Upon activation, MerTK promotes the engulfment of apoptotic cells by phagocytes, contributing to tissue repair and immune tolerance. Moreover, MerTK activation can also influence downstream signaling pathways, including those related to cell survival and proliferation. Therefore, MerTK activators have the potential to be valuable tools for research aimed at understanding the molecular mechanisms underlying immune regulation and tissue homeostasis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a natural phenol found in grapes and berries. Studies have suggested that it can enhance MerTK expression, potentially contributing to its anti-inflammatory and immunomodulatory effects. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Found in turmeric, curcumin has been reported to increase MerTK expression. This may be linked to its well-documented anti-inflammatory properties and its role in promoting the clearance of apoptotic cells. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine is a polyamine that has been found to increase MerTK expression. This may be associated with its ability to extend lifespan and its role in autophagy and cellular homeostasis. | ||||||
Palmitoylethanolamide | 544-31-0 | sc-202754 sc-202754A sc-202754B sc-202754C sc-202754D | 10 mg 50 mg 500 mg 1 g 10 g | $78.00 $238.00 $2050.00 $3274.00 $16330.00 | ||
Palmitoylethanolamide is a fatty acid amide that has been reported to enhance MerTK expression. This could contribute to its anti-inflammatory and analgesic effects. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid found in many fruits and vegetables. It has been shown to increase MerTK expression, potentially linking to its antioxidant and anti-inflammatory properties. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride has been reported to upregulate MerTK expression. This may be associated with its role in modulating immune responses and its potential neuroprotective effects. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, has been reported to increase MerTK expression. This may be linked to its role in immune modulation and tissue repair. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 has been shown to upregulate MerTK expression. This could contribute to its role in resolving inflammation and promoting the clearance of apoptotic cells. | ||||||