megalin Inhibitors
Megalin Inhibitors target and modulate the activity of the megalin protein, also known as LRP2 (Low-Density Lipoprotein Receptor-Related Protein 2). Megalin is a large, multi-ligand endocytic receptor expressed on the cell surface of various tissues, particularly in the proximal tubules of the kidney and the absorptive epithelial cells of the small intestine. Structurally, megalin consists of several domains, including a series of cysteine-rich complement-type repeats that allow it to interact with numerous ligands and mediate their internalization into cells through endocytosis.
The functions of megalin are diverse and pivotal to various physiological processes, primarily related to the uptake and transport of ligands from the extracellular environment into cells. Megalin plays a central role in the reabsorption of essential proteins and nutrients from the glomerular filtrate in the kidneys, preventing their loss in urine. It is involved in the uptake of molecules such as vitamin D-binding protein, albumin, and hormones like insulin, thyroid hormones, and parathyroid hormone, among others. In the small intestine, megalin contributes to the absorption of dietary nutrients, vitamins, and other bioactive compounds. Additionally, megalin has been implicated in signaling pathways and cellular processes beyond endocytosis, including cell adhesion, intracellular signaling, and cellular differentiation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
As an mTOR inhibitor, Rapamycin can specifically reduce megalin expression by inhibiting the mTOR pathway, which is crucial for protein synthesis and cellular growth processes involved in the production of megalin. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
This compound, known for affecting lysosomal function and autophagy, can disrupt the lysosomal degradation of megalin, leading to altered processing and functionality of this endocytic receptor. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $296.00 | 7 | |
By inhibiting sodium channels, Amiloride can indirectly diminish megalin's role in renal tubular reabsorption, affecting the receptor's function in renal processes. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
As a V-ATPase inhibitor, Bafilomycin A1 impacts vesicular acidification, crucial for megalin's endocytic function, potentially leading to impaired megalin-mediated endocytosis. | ||||||
Phloridzin dihydrate | 7061-54-3 | sc-215708 sc-215708A | 250 mg 1 g | $49.00 $119.00 | ||
This SGLT inhibitor can indirectly influence megalin's function in renal glucose reabsorption, suggesting a potential impact on megalin's overall activity in the kidney. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $57.00 $245.00 $831.00 $1331.00 | 4 | |
As a macrolide antibiotic that interferes with protein synthesis, Erythromycin can potentially reduce the synthesis and subsequent expression of megalin. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $29.00 $90.00 $339.00 | 12 | |
By inhibiting HMG-CoA reductase and impacting cholesterol synthesis, Lovastatin may influence the cell membrane dynamics and expression of megalin. | ||||||
Doxycycline-d6 | 564-25-0 unlabeled | sc-218274 | 1 mg | $16500.00 | ||
This tetracycline antibiotic, known to interfere with protein synthesis, could lead to decreased expression of megalin by inhibiting its synthesis. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
An immunomodulator that affects protein trafficking and endocytosis, Cyclosporine A might influence the trafficking and functional expression of megalin. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Alters intracellular signaling pathways, which could impact megalin's function in the kidney, particularly in terms of receptor trafficking and signal transduction. | ||||||