MDC1 Activators
MDC1 activators encompass a specific set of chemical compounds that can directly or indirectly bolster the activity of the MDC1 protein. MDC1, short for Mediator of DNA damage checkpoint 1, plays a pivotal role in the DNA damage response pathway, ensuring that the cellular machinery responds appropriately to genetic aberrations. The chemicals classified under this category predominantly induce DNA damage, which in turn compels MDC1 to spring into action, coordinating the DNA damage response and repair.
For instance, Bleomycin introduces DNA double-strand breaks, prompting MDC1 to rally to these damage sites and facilitate the requisite signaling. Similarly, compounds like Etoposide inhibit specific enzymes like topoisomerase II, resulting in DNA breaks that inevitably summon MDC1 to partake in the repair mechanism. The DNA crosslinks and adducts instigated by Cisplatin elicit a similar response, driving MDC1 to partake in the repair sequences. Chemicals such as Hydrogen Peroxide and Doxorubicin, known for inducing oxidative DNA damage and intercalating DNA respectively, also usher in MDC1's mediation in the aftermath of their impact.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $275.00 | 5 | |
Introduces DNA double-strand breaks, leading to MDC1 recruitment to the damage sites for effective DNA damage signaling. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
By inhibiting topoisomerase II and causing DNA breaks, it prompts MDC1 to converge at these break sites for repair processes. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Forms DNA adducts and crosslinks, which summon MDC1 to participate in the DNA repair processes. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
By inducing oxidative DNA damage, it necessitates the recruitment of MDC1 to mediate the damage response. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Generates DNA breaks by intercalation, leading to MDC1 activation and its association with damage sites. | ||||||
Methyl methanesulfonate | 66-27-3 | sc-250376 sc-250376A | 5 g 25 g | $56.00 $133.00 | 2 | |
By alkylating DNA and forming adducts, it engages MDC1 in the orchestration of the DNA damage response. | ||||||
4-Nitroquinoline N-oxide | 56-57-5 | sc-256815 sc-256815A | 1 g 5 g | $124.00 $421.00 | 6 | |
As a DNA intercalating agent causing DNA damage, it brings MDC1 into action to mediate repair mechanisms. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Causes DNA crosslinks, hence recruiting MDC1 to help coordinate the appropriate response to such damage. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Its inhibition of DNA topoisomerase I, leading to DNA breaks, requires the mediation of MDC1 in the subsequent damage response. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Upon misincorporation into DNA, it causes damage, prompting MDC1 to participate in the repair and damage signaling processes. | ||||||