MCART6 Inhibitors
MCART6 inhibitors function by targeting various aspects of mitochondrial physiology to exert their inhibitory effects. The primary mechanism involves the disruption of mitochondrial membrane potential and permeability, pivotal factors in the proper functioning of MCART6. Certain cyclic peptides have the capacity to interfere with this membrane potential, which is crucial for the activity of MCART6 within the mitochondrial matrix. Furthermore, the inhibition of mitochondrial ATP synthase by specific inhibitors results in diminished ATP production, a scenario under which MCART6's function is compromised, owing to its reliance on the mitochondrial energy status. Ionophores that selectively transport potassium ions across mitochondrial membranes can collapse the potential, thereby impeding MCART6 activity by altering the ionic homeostasis essential for its operation.
Additionally, the inhibition of various mitochondrial complexes like I, II, III, and IV by distinct chemical entities leads to the reduction of electron transport, ultimately affecting the mitochondrial membrane potential and MCART6 function. Compounds that inhibit the adenine nucleotide translocator restrict the exchange of ADP and ATP across the mitochondrial inner membrane, which can indirectly inhibit MCART6 through alterations in mitochondrial nucleotide levels. Metal complexes that hinder mitochondrial function by obstructing complexes II and III of the electron transport chain contribute to the indirect inhibition of MCART6 by disrupting mitochondrial electron flux.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
A cyclic peptide that interferes with the mitochondrial membrane potential and permeability. By affecting these properties, Cyclosporin A can indirectly inhibit MCART6 by altering the mitochondrial environment where MCART6 is active. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $175.00 $600.00 $1179.00 $5100.00 $9180.00 | 26 | |
An inhibitor of mitochondrial ATP synthase, which leads to a decrease in mitochondrial ATP production. This reduction can impair MCART6 function, as MCART6 activity is linked to mitochondrial energy status. | ||||||
Bongkrekic acid | 11076-19-0 | sc-205606 | 100 µg | $418.00 | 10 | |
An ANT inhibitor that locks the translocator in a conformation favoring ATP retention inside mitochondria. By affecting ADP/ATP exchange, bongkrekic acid can indirectly inhibit MCART6 activity. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $92.00 $348.00 | 46 | |
A protonophore that uncouples oxidative phosphorylation by dissipating the proton gradient across the mitochondrial membrane. This collapse can indirectly inhibit MCART6 by affecting the mitochondrial membrane potential. | ||||||
Valinomycin | 2001-95-8 | sc-200991 | 25 mg | $163.00 | 3 | |
An ionophoric compound that promotes potassium ion transport across mitochondrial membranes, collapsing the potential and indirectly affecting MCART6 by altering the ionic homeostasis of mitochondria. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
An inhibitor of mitochondrial complex I. By inhibiting electron transport, rotenone decreases mitochondrial membrane potential, which can in turn indirectly inhibit MCART6 by affecting its mitochondrial context. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
A specific inhibitor of mitochondrial complex III, reducing electron transport and thus affecting the mitochondrial membrane potential. This change in the mitochondrial environment can indirectly inhibit MCART6. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
A metal complex that can disrupt mitochondrial function by inhibiting complex II and III of the electron transport chain. This disruption can indirectly inhibit MCART6 by affecting mitochondrial electron flux. | ||||||
2-Thenoyltrifluoroacetone | 326-91-0 | sc-251801 | 5 g | $36.00 | 1 | |
A compound that inhibits mitochondrial complex II, leading to a reduction in electron transport and a decrease in mitochondrial membrane potential, which can indirectly inhibit MCART6 by affecting mitochondrial function. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $42.00 $152.00 $385.00 $845.00 $88.00 | 8 | |
An inhibitor of mitochondrial complex IV which impedes electron transport, resulting in a loss of mitochondrial membrane potential and subsequent indirect inhibition of MCART6 by altering mitochondrial function. | ||||||