MBP-probe Inhibitors
MBP-probe inhibitors are a class of chemical compounds that have garnered significant attention in the field of molecular biology and biochemistry. These inhibitors are specifically designed to target and interact with the Myelin Basic Protein (MBP) and its associated probes. MBP is a crucial component of the central nervous system, primarily found in the myelin sheath that envelops nerve fibers. This protein plays a vital role in insulating and protecting nerve fibers, facilitating efficient signal transmission within the nervous system. MBP-probe inhibitors are synthetic or naturally occurring molecules that are engineered to interfere with the binding or activity of MBP probes, which are often used as research tools to study the function and regulation of MBP in various biological processes.
The development and use of MBP-probe inhibitors have provided valuable insights into the intricate mechanisms of myelin formation, maintenance, and degradation. By selectively modulating the interactions between MBP and its probes, researchers can unravel the molecular pathways involved in myelin-related disorders, such as multiple sclerosis and leukodystrophies. Additionally, these inhibitors have proven to be invaluable in elucidating the fundamental biology of MBP, shedding light on its post-translational modifications, cellular localization, and functional roles beyond myelin formation. Overall, MBP-probe inhibitors serve as essential tools in the scientific community, enabling a deeper understanding of the complex biology of MBP and its implications in neurological health and disease.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound is a cytidine analog that can be incorporated into DNA, where it inhibits DNA methyltransferases, leading to a reduction in DNA methylation. Decreased DNA methylation can result in the activation of previously silenced genes, potentially influencing protein expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. It increases acetylation of histones, which is generally associated with an open chromatin structure and active transcription. This could lead to changes in the expression of various proteins, depending on the context. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D intercalates into DNA and inhibits RNA polymerase, leading to inhibition of RNA synthesis. This can result in a decrease in the production of mRNA and subsequently, protein expression. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide inhibits protein synthesis in eukaryotic organisms by interfering with the translocation step in protein synthesis, leading to a decrease in protein production. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin binds to the mTOR complex and inhibits its activity, which can lead to a decrease in protein synthesis. mTOR is a key regulator of cell growth and protein synthesis, and its inhibition can influence the expression of various proteins. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
α-Amanitin is a potent inhibitor of RNA polymerase II, leading to inhibition of mRNA synthesis and subsequently, protein expression. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate is a folate analog that inhibits dihydrofolate reductase, leading to a decrease in tetrahydrofolate and its derivatives. This can result in impaired synthesis of purines and thymidylate, affecting DNA synthesis and repair, and potentially influencing protein expression. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin binds to heat shock protein 90 (Hsp90) and inhibits its chaperone activity, which can lead to the degradation of client proteins and potentially reduce their expression levels. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is a proteasome inhibitor that prevents the degradation of ubiquitinated proteins, leading to an accumulation of misfolded or damaged proteins in the cell. This can result in cell cycle arrest and apoptosis, potentially reducing protein expression. | ||||||
Emetine | 483-18-1 | sc-470668 sc-470668A sc-470668B sc-470668C | 1 mg 10 mg 50 mg 100 mg | $440.00 $900.00 $1400.00 $2502.00 | ||
Emetine inhibits protein synthesis by binding to the 40S ribosomal subunit, leading to a decrease in protein production. | ||||||