MBD2 Activators
MBD2 activators comprise a chemical class of compounds designed to interact with and modulate the activity of Methyl-CpG Binding Domain 2 (MBD2) proteins. MBD2 belongs to a family of MBD proteins that play a pivotal role in the epigenetic regulation of gene expression. These proteins are instrumental in interpreting DNA methylation patterns within the genome, which involve the addition of methyl groups to specific cytosine residues in DNA. MBD2, with its methyl-CpG-binding domain, can selectively recognize and bind to methylated DNA sequences, influencing gene silencing and chromatin structure.
The influence of MBD2 activators on MBD2 function is achieved through a variety of mechanisms. These compounds can interact directly with MBD2, affecting its binding affinity to methylated DNA or altering its interactions with other epigenetic regulators. Consequently, these activators have the capacity to reshape the epigenetic landscape of cells, which can lead to alterations in gene expression profiles and cellular behaviors. The study of MBD2 activators holds significant importance in the realm of epigenetics, as it provides a deeper understanding of the processes by which DNA methylation and proteins like MBD2 contribute to gene regulation and cellular function.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor; reduces DNA methylation, potentially altering MBD2 binding to methylated DNA. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Similar to 5-Azacytidine, it inhibits DNA methyltransferase, potentially affecting MBD2's interaction with DNA. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
A methyl donor in various methylation reactions; could influence DNA methylation patterns, indirectly affecting MBD2 activity. | ||||||
Methylstat | 1310877-95-2 | sc-507374 | 10 mg | $480.00 | ||
A histone methyltransferase inhibitor; indirectly impacts DNA methylation and chromatin structure, potentially influencing MBD2. | ||||||
1-Hydrazinophthalazine Hydrochloride | 304-20-1 | sc-206167 | 10 g | $280.00 | ||
A DNA methyltransferase inhibitor; may affect MBD2 activity by altering DNA methylation patterns. | ||||||
Procaine | 59-46-1 | sc-296134 sc-296134A sc-296134B sc-296134C | 25 g 50 g 500 g 1 kg | $110.00 $193.00 $407.00 $628.00 | 1 | |
A DNA methyltransferase inhibitor; could indirectly modify the interaction of MBD2 with methylated DNA. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A polyphenol found in green tea; has been reported to influence DNA methylation, potentially affecting MBD2 activity. | ||||||