MATH-5 Inhibitors
MATH-5 (atonal bHLH transcription factor 7) inhibitors encompass a variety of chemical compounds that interact with different cellular signaling pathways, ultimately leading to the decreased functional activity of MATH-5. Specifically, some of these compounds inhibit kinase activity, which is crucial for the phosphorylation that regulates transcription factor functions, including those of MATH-5. Kinase inhibitors, by modulating phosphorylation states, have the ability to alter the activity of MATH-5 indirectly. Similarly, inhibition of the PI3K/Akt pathway affects cellular signaling contexts, which may impact the functional state of MATH-5 by preventing the activation of downstream targets that could be necessary for MATH-5's activity. Inhibition of the mTOR signaling pathway also results in reduced protein synthesis and may affect transcription factor activity, potentially leading to an indirect inhibition of MATH-5 due to decreased protein availability or altered regulatory mechanisms.
Furthermore, compounds that interfere with specific signaling pathways such as Hedgehog, TGF-beta, or Wnt/β-catenin can modulate the transcriptional profile of cells, thereby influencing the activity of transcription factors like MATH-5. For instance, the disruption of Smoothened within the Hedgehog pathway can alter downstream transcriptional events that affect MATH-5 activity. Inhibitors of proteasome function may lead to an accumulation of regulatory proteins that compete with or destabilize MATH-5, while compounds that affect the hypoxic response in cells can shift transcriptional dynamics, indirectly affecting MATH-5 activity. Moreover, cell cycle inhibitors that target CDKs can impact MATH-5 by altering cell cycle-dependent signaling pathways, potentially leading to reduced MATH-5 activity.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent kinase inhibitor that, by inhibiting a range of kinases, can modulate phosphorylation states of proteins including transcription factors like MATH-5, leading to its functional inhibition. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Inhibits Smoothened (SMO), a component of the Hedgehog signaling pathway, which can alter the transcriptional activity of MATH-5 by affecting the localization and expression of downstream transcription factors. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that prevents Akt activation, reducing the phosphorylation and activation of downstream targets, potentially impacting MATH-5 activity due to altered cellular signaling contexts. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that can lead to reduced protein synthesis and altered transcription factor activity, thereby potentially inhibiting MATH-5 function by decreasing its availability or altering its regulatory mechanisms. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A MEK inhibitor that disrupts the MAPK/ERK pathway, potentially leading to reduced transcriptional regulation by MATH-5 due to changes in phosphorylation patterns of associated proteins or MATH-5 itself. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
An inhibitor of the TGF-beta receptor that can modulate transcription factor activity and thereby influence MATH-5 function due to changes in cellular differentiation signals. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that can lead to increased levels of regulatory proteins that may compete with or destabilize MATH-5, indirectly inhibiting its function. | ||||||
Chetomin | 1403-36-7 | sc-202535 sc-202535A | 1 mg 5 mg | $182.00 $661.00 | 10 | |
Disrupts the function of hypoxia-inducible factor (HIF), which may indirectly affect MATH-5 activity by altering the transcriptional response under hypoxic conditions. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
A cyclin-dependent kinase (CDK) inhibitor that may hinder cell cycle progression and transcription factor dynamics, potentially reducing MATH-5 activity as a result of altered cell cycle-dependent signaling. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
An MEK inhibitor that prevents activation of ERK, likely leading to lessened transcriptional regulation by MATH-5 due to the impact on MAPK signaling pathway. | ||||||