MAT I Activators
MAT I Activators encompass a suite of chemical compounds that bolster the enzyme's function through the augmentation of substrate availability and the provision of necessary cofactors. Betaine and choline contribute to the conservation of methionine, the primary substrate for MAT I, by acting as alternative methyl donors, thereby indirectly enhancing the enzyme's capacity to generate S-adenosylmethionine (SAMe). Simultaneously, the pivotal role of vitamins such as B12 and folic acid in the homocysteine remethylation cycle ensures a steady supply of methionine, underpinning the sustained activity of MAT I. Moreover, the synergistic action of methionine and ATP as direct substrates is straightforward: by elevating their concentrations, MAT I enzymatic activity is directly stimulated, thus fostering an efficient production of SAMe. Magnesium and zinc serve as vital cofactors that not only activate MAT I but also may enhance its structural stability, ensuring optimal enzymatic performance.
Essential cofactors such as pyridoxal phosphate (vitamin B6) and riboflavin (vitamin B2) are also instrumental in the activation of MAT I. Pyridoxal phosphate is crucial for the enzymatic conversion of homocysteine to methionine, further supporting MAT I by increasing its substrate pool. Riboflavin, as a precursor for the biosynthesis of flavin adenine dinucleotide (FAD), is involved in the same homocysteine remethylation pathway, indirectly facilitating MAT I activity by ensuring the regeneration of methionine. Additionally, the supplementation of S-adenosylmethionine itself may exert a stabilizing feedback effect on MAT I, potentially enhancing its catalytic efficiency. Collectively, these activators work in concert to ensure that MAT I operates at an optimal level, thereby maintaining the crucial biological processes that depend on the generation of S-adenosylmethionine.
SEE ALSO...
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $180.00 $655.00 | 2 | |
S-Adenosylmethionine (SAMe) is a substrate product of MAT I that can act as an allosteric activator. Its increased concentration within the cell could enhance the activity of MAT I by feedback activation, ensuring a sufficient supply of this methyl donor for various methylation reactions. | ||||||
L-Methionine | 63-68-3 | sc-394076 sc-394076A sc-394076B sc-394076C sc-394076D sc-394076E | 25 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $36.00 $56.00 $148.00 $566.00 $1081.00 | ||
Methionine serves as the amino acid substrate for MAT I. An abundance of methionine can increase the enzymatic activity of MAT I, as it directly provides the substrate required for the production of S-Adenosylmethionine. | ||||||
Betaine | 107-43-7 | sc-214595 sc-214595A sc-214595B sc-214595C sc-214595D sc-214595E | 50 g 100 g 250 g 1 kg 2.5 kg 5 kg | $30.00 $40.00 $55.00 $160.00 $330.00 $580.00 | 2 | |
Betaine donates a methyl group to homocysteine to form methionine through the betaine-homocysteine methyltransferase pathway. Increased levels of betaine can thus indirectly enhance MAT I activity by increasing the substrate availability (methionine). | ||||||
Vitamin B12 | 68-19-9 | sc-296695 sc-296695A sc-296695B sc-296695C sc-296695D sc-296695E | 100 mg 1 g 5 g 25 g 100 g 1 kg | $39.00 $55.00 $204.00 $877.00 $3414.00 $9180.00 | 2 | |
Vitamin B12 is a cofactor for methionine synthase in the conversion of homocysteine to methionine. Higher availability of vitamin B12 can increase methionine levels and indirectly enhance MAT I activity through substrate availability. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $72.00 | 2 | |
Folic acid is involved in the remethylation of homocysteine to methionine, with the help of methionine synthase. An adequate supply of folic acid can indirectly enhance MAT I activity by increasing methionine concentrations. | ||||||
Choline chloride | 67-48-1 | sc-207430 sc-207430A sc-207430B | 10 mg 5 g 50 g | $32.00 $36.00 $51.00 | 1 | |
Choline can be oxidized to betaine, which in turn can donate a methyl group to homocysteine to form methionine. Hence, increased choline levels can enhance MAT I activity by raising methionine levels. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc is a necessary cofactor for MAT I. Adequate zinc levels ensure proper MAT I conformation and function, directly enhancing its activity. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD+ can influence the activity of MAT I indirectly by being a co-substrate for reactions that regenerate methionine from homocysteine, thereby increasing MAT I substrate availability. | ||||||
ATP | 56-65-5 | sc-507511 | 5 g | $17.00 | ||
ATP provides the adenosyl group for the reaction catalyzed by MAT I, making it a direct participant in the enzymatic process. Higher ATP levels can enhance MAT I activity by ensuring the availability of this necessary group. | ||||||
Homocysteine | 6027-13-0 | sc-507315 | 250 mg | $195.00 | ||
While homocysteine is not an activator, its regulated levels are essential for the balance of methionine synthesis. Optimized homocysteine concentration can help maintain a steady state of MAT I activity. | ||||||