MASP-3 Activators
MASP-3 activators are a specialized category of chemical compounds that target and boost the activity of MASP-3 (Mannan-binding lectin-associated serine protease 3), an enzyme pivotal to the lectin pathway of the complement system. This pathway is part of the innate immune defense mechanism, responsible for pathogen recognition and initiation of an inflammatory response. MASP-3 plays a unique role in this pathway by cleaving pro-factor D into factor D, a crucial activator of the complement cascade.
These activators can enhance the function of MASP-3 through several potential mechanisms. Direct activators may interact with MASP-3 in a manner that stabilizes its active confirmation or increases its affinity for substrates. This could involve binding to regions of the enzyme that are not the active site but are critical for its overall structure and function, thus promoting its enzymatic activity. Indirect activators, on the other hand, might not bind to MASP-3 itself but rather influence the expression levels of the protein by upregulating gene transcription or by stabilizing the mRNA, leading to increased synthesis of MASP-3. Alternatively, they could modulate the post-translational modifications of MASP-3, such as glycosylation patterns, which can significantly affect the enzyme's stability and interaction with other complement components.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases the production of cAMP by activating adenylyl cyclase. MASP-3 is involved in cAMP-dependent signaling pathways, and this increase in cAMP can enhance its functional activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX works as a non-specific inhibitor of phosphodiesterases (PDEs), which leads to an increase in cAMP levels in cells. MASP-3 is part of cAMP-dependent signaling pathways, and this increase in cAMP levels can enhance the functional activity of MASP-3. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a specific inhibitor of PDE4, which increases intracellular cAMP by preventing its breakdown. MASP-3 is part of cAMP-dependent signaling pathways, and this increase in cAMP levels can enhance the functional activity of MASP-3. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine promotes the activity of adenylyl cyclase via beta-adrenergic receptors, leading to increased cAMP levels. MASP-3 is involved in cAMP-dependent signaling pathways, and this increase in cAMP levels can enhance the functional activity of MASP-3. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC can phosphorylate and activate MASP-3, enhancing its functional activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid serves as a potent inhibitor of protein phosphatases PP1 and PP2A. It increases the phosphorylation levels of proteins, including MASP-3, enhancing its functional activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A inhibits protein phosphatases PP1 and PP2A, which leads to increased phosphorylation levels of proteins. MASP-3, being one of these proteins, can have its functional activity enhanced due to this. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine acts as a potent inhibitor of protein kinases, which can alter the phosphorylation status of MASP-3, enhancing its functional activity. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Vanadate is a potent inhibitor of protein tyrosine phosphatases. It can enhance the phosphorylation status of proteins, including MASP-3. | ||||||