MARCO Activators
The protein MARCO, or Macrophage Receptor with Collagenous Structure, is a crucial component of the innate immune system, predominantly expressed on the surface of macrophages. Its primary function revolves around the recognition and clearance of various pathogens, apoptotic cells, and foreign particles through the process of phagocytosis. MARCO acts as a pattern recognition receptor (PRR), utilizing its extracellular domain containing collagenous regions to bind to a diverse array of ligands, including pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Upon ligand binding, MARCO initiates downstream signaling events that trigger the internalization of the bound particles, facilitating their degradation within the macrophage. This process is essential for the elimination of invading microorganisms and cellular debris, thereby promoting host defense and tissue homeostasis.
Activation of MARCO occurs through various mechanisms, primarily involving ligand-induced signaling pathways that initiate phagocytosis. Upon ligand binding, MARCO undergoes conformational changes that lead to the recruitment and activation of intracellular signaling molecules, such as kinases and adaptor proteins. These signaling cascades culminate in the rearrangement of the cytoskeleton and membrane dynamics necessary for the formation of phagocytic cups and engulfment of the bound particles. Additionally, activation of MARCO may also involve the modulation of its expression levels or subcellular localization in response to environmental cues or immune stimuli. Overall, the activation of MARCO plays a pivotal role in innate immune responses by enhancing the phagocytic capacity of macrophages and promoting the efficient clearance of pathogens and cellular debris from the host.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074 is an ERK1/2 inhibitor, and its inhibition leads to activation of the MAPK pathway. By enhancing MAPK signaling, GW5074 indirectly activates MARCO. The heightened MAPK activity influences the cellular processes that regulate MARCO expression, promoting its activation within the cell. | ||||||
2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester | 305834-79-1 | sc-479756 | 25 mg | $380.00 | ||
Also called SC79, this compound is an Akt activator that stimulates the PI3K/Akt signaling pathway. Through activation of Akt, SC79 indirectly activates MARCO by modulating the cellular events governed by the PI3K/Akt pathway. This activation influences the regulation of MARCO expression and function within the cell. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels. Elevated cAMP indirectly activates MARCO by influencing downstream events, possibly through the cAMP/PKA signaling pathway. The modulation of this pathway alters cellular processes that contribute to the activation of MARCO within the cell. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, a NAD-dependent deacetylase. SIRT1 activation indirectly activates MARCO by influencing cellular processes regulated by SIRT1. The activation of SIRT1 alters the acetylation status of proteins involved in MARCO regulation, promoting its activation within the cell. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR is an AMP-activated protein kinase (AMPK) activator. Its activation of AMPK influences the AMPK signaling pathway, indirectly activating MARCO. The activated AMPK alters cellular processes that contribute to the activation of MARCO within the cell. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a protein phosphatase inhibitor that activates kinases such as MAPK. By inhibiting protein phosphatases, it indirectly activates MARCO through enhanced MAPK signaling. The heightened MAPK activity influences the cellular processes that regulate MARCO expression, promoting its activation within the cell. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor. Its inhibition of DNA methyltransferases leads to altered DNA methylation patterns, indirectly activating MARCO. Changes in DNA methylation status influence the cellular processes that regulate MARCO expression, promoting its activation within the cell. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $33.00 $77.00 $120.00 | 14 | |
FTY720 is a sphingosine-1-phosphate (S1P) receptor modulator. By influencing S1P receptors, FTY720 indirectly activates MARCO. The modulation of S1P receptors alters cellular processes that contribute to the activation of MARCO within the cell. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $58.00 $188.00 $884.00 | 10 | |
GSK-3 Inhibitor IX activates the Wnt pathway. By activating Wnt signaling, BIO indirectly activates MARCO through the Wnt pathway. The activated Wnt pathway influences the cellular processes that regulate MARCO expression, promoting its activation within the cell. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase (HDAC) inhibitor. By inhibiting HDAC, it alters histone acetylation patterns, indirectly activating MARCO. Changes in histone acetylation influence the cellular processes that regulate MARCO expression, promoting its activation within the cell. | ||||||