MAP-1S Inhibitors
MAP-1S inhibitors belong to a class of chemical compounds designed to target and modulate the activity of the Microtubule-Associated Protein 1S (MAP-1S) protein. MAP-1S is a relatively lesser-known microtubule-associated protein that plays a role in regulating microtubule dynamics within cells. Microtubules are essential components of the cytoskeleton, involved in various cellular processes such as cell division, intracellular transport, and maintenance of cell shape. MAP-1S is believed to participate in microtubule organization and stability, although its precise functions are still being elucidated. Inhibitors of MAP-1S are developed to interact with this protein, disrupting its role in microtubule regulation and influencing cellular processes dependent on microtubules.
These inhibitors are typically small molecules or compounds designed to bind to MAP-1S, affecting its interactions with microtubules or other regulatory proteins. By interfering with the binding of MAP-1S to microtubules, these inhibitors may impact microtubule stability, organization, and dynamics within the cell. Research into MAP-1S inhibitors can provide valuable insights into the intricate mechanisms governing microtubule function and organization, contributing to our understanding of fundamental cellular processes such as cell division and intracellular transport.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
A microtubule-depolymerizing agent that disrupts microtubule dynamics, potentially downregulating MAP1S expression due to altered microtubule turnover. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Stabilizes microtubules and may affect MAP1S expression by preventing microtubule disassembly, which is essential for autophagy regulation. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Binds to tubulin and inhibits microtubule formation, possibly influencing MAP1S levels by altering microtubule-associated processes. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Binds tubulin, preventing polymerization into microtubules, which may indirectly reduce MAP1S expression through impaired microtubule dynamics. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $168.00 | ||
An inhibitor of autophagy that promotes the degradation of Vps34 PI3 kinase complexes, possibly lowering MAP1S expression by inhibiting autophagy. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
An inhibitor of autophagy through PI3K inhibition, which might reduce MAP1S expression by blocking autophagosome formation. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
A specific inhibitor of V-ATPase that prevents autophagosome-lysosome fusion, potentially leading to decreased MAP1S expression. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Prevents autophagosome fusion and lysosome acidification, possibly affecting MAP1S expression by disrupting autophagy. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
An inhibitor of PI3K and autophagy, which may downregulate MAP1S expression by blocking autophagic vesicle formation. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Stabilizes microtubules and could affect MAP1S expression through similar mechanisms as paclitaxel. | ||||||