MAO-A Activators
Monoamine oxidase A (MAO-A) is one of two primary isoforms of the enzyme monoamine oxidase, with the other being MAO-B. This enzyme is primarily found in the mitochondrial outer membrane of several cell types, including neurons and liver cells. As the name suggests, MAO-A activators are molecules that enhance or stimulate the activity of the MAO-A enzyme. By doing so, these activators influence the metabolic breakdown of key neurotransmitters, particularly serotonin, norepinephrine, and dopamine. The process of oxidatively deaminating these monoamines plays a pivotal role in maintaining neurotransmitter homeostasis within the brain and throughout the body.
The chemical structures of MAO-A activators can be diverse, but they typically possess specific motifs or functionalities that interact with the enzyme's active site or allosteric sites, leading to its activation. It's essential to note that the molecular interactions between the activator and the enzyme can vary, with some activators binding directly to the active site and others influencing the enzyme's conformation to make it more receptive to its natural substrates. Furthermore, the potency and specificity of these activators can vary, with some having a stronger affinity for MAO-A over MAO-B, while others might be non-selective.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, found in grapes and red wine, has been shown to upregulate MAO-A expression. The mechanism is not fully understood, but it may involve its antioxidant properties influencing neural health. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a component of turmeric, might elevate MAO-A levels. Its anti-inflammatory and antioxidant properties could modulate neurotransmitter pathways and subsequently affect MAO-A expression. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine can influence several neurotransmitter systems. It has been proposed that through adenosine receptor antagonism, caffeine may indirectly influence MAO-A expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium, a mood stabilizer, has been shown to influence various neurotransmitter systems. It may indirectly modulate MAO-A expression through its effects on intracellular signaling pathways. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Tretinoin, a form of vitamin A, can influence cell differentiation and growth. There's evidence that it may induce MAO-A expression in specific neuronal cell contexts. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin can elevate cyclic AMP (cAMP) levels, leading to protein kinase A activation. This pathway may influence the transcription and expression of several genes, including MAO-A. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a histone deacetylase (HDAC) inhibitor. By influencing chromatin structure and gene expression, it might play a role in upregulating MAO-A in certain conditions. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, a glucocorticoid, can affect many cellular pathways. It has been shown to modulate neurotransmitter systems and could potentially influence MAO-A expression indirectly. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, found in cruciferous vegetables, possesses antioxidant properties. It might affect MAO-A expression through its ability to modulate oxidative stress and related pathways. | ||||||