MAN2C1 Activators
The chemical class known as MAN2C1 Activators refers to a group of compounds that specifically target and modulate the activity of the enzyme MAN2C1, which stands for Mannosidase Alpha Class 2C Member 1. This enzyme is part of the glycosyl hydrolase family and is involved in the processing of N-linked glycans during their maturation in the endoplasmic reticulum and Golgi apparatus. Glycans are complex carbohydrates attached to proteins and lipids, playing a pivotal role in cellular processes such as protein folding, stability, and signaling. MAN2C1 is an enzyme that catalyzes the hydrolysis of the mannose residues from the N-linked glycoproteins, a step crucial for the proper trimming and subsequent remodeling of the glycan structures. MAN2C1 Activators enhance the activity of this enzyme, thereby influencing the glycan processing pathways.
The mechanisms by which MAN2C1 Activators exert their effects involve the direct interaction with the MAN2C1 enzyme, which may lead to an increase in its catalytic efficiency or stabilization of its active form. These activators can be small molecules, peptides, or other types of chemical agents that have been designed or discovered based on their ability to bind to the MAN2C1 enzyme and augment its function. The structure-activity relationship (SAR) of these activators is a subject of interest because it provides insights into the molecular interactions necessary for the activation of MAN2C1. By modulating the function of MAN2C1, these activators can influence the glycosylation patterns of proteins, which may have various downstream effects on cellular physiology. The development and study of MAN2C1 Activators contribute to the broader field of glycobiology and the understanding of glycan-related processes within cells. These activators are valuable tools for researchers investigating the role of glycan modification in cellular mechanisms and the intricate workings of enzymes like MAN2C1 in glycan processing.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing intracellular cAMP levels. This rise in cAMP can result in the activation of PKA (protein kinase A) which may subsequently phosphorylate MAN2C1, thereby enhancing its enzymatic activity involved in glycoprotein processing. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Isobutylmethylxanthine (IBMX) is a non-selective inhibitor of phosphodiesterases, leading to an increased intracellular concentration of cAMP, which could activate PKA and potentially enhance the activity of MAN2C1 by increasing phosphorylation states that favor its active conformation. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
D-erythro-Sphingosine-1-phosphate acts through its receptors to activate intracellular signaling pathways such as PI3K/Akt, which may lead to downstream effects that enhance the activity of MAN2C1 by promoting its proper folding and stability within the ER-Golgi network. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which can phosphorylate a wide array of substrates. Through PKC's broad signaling impact, it could enhance the activity of MAN2C1 by influencing its phosphorylation state. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of PI3K. By inhibiting PI3K, it may affect the balance of cellular signaling pathways, potentially enhancing the activity of MAN2C1 by reducing competing signaling pathways that result in its inactivation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels, potentially activating calcium-dependent protein kinases that could phosphorylate and enhance the activity of MAN2C1. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. By inhibiting certain kinases, it might selectively enhance MAN2C1 activity by reducing inhibitory phosphorylation events. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to increased cytosolic calcium levels, which may activate MAN2C1 through calcium-dependent signaling mechanisms. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor which could enhance the activity of MAN2C1 by preventing its deactivation through tyrosine kinase-mediated phosphorylation, thus maintaining it in an active state. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB 203580 is a p38 MAPK inhibitor, potentially shifting the equilibrium of cellular signaling pathways to favor those that activate MAN2C1 or maintain its activity by preventing deactivation through this pathway. | ||||||