MAN1A1 Activators
MAN1A1, a crucial enzyme situated within the Golgi apparatus, plays a role in the essential process of glycoprotein processing. The complex nature of protein glycosylation within the cell requires a harmonious interaction between various enzymes and pathways. Any disruption or modification in these pathways can lead to compensatory mechanisms, wherein enzymes like MAN1A1 might experience shifts in their activity. The chemicals listed, such as Brefeldin A and Monensin, exert their influence by modulating different aspects of cellular pathways tied to glycoprotein processing. For instance, by altering Golgi function or by perturbing protein trafficking routes, they create a cellular environment where enzymes like MAN1A1 can see shifts in their activity. Similarly, compounds like 2-Deoxy-D-glucose (2-DG) and Thapsigargin modulate the glycosylation process either by acting as analogs or by inducing cellular stress, respectively.
Such modulations in the glycosylation pathway lead to a demand for specific enzymatic activities. In a cellular attempt to maintain homeostasis and ensure proper glycoprotein processing, enzymes related to these pathways, like MAN1A1, can be indirectly activated. For instance, compounds like Concanavalin A A, by binding to mannose residues on glycoproteins, can increase the demand for mannosidase activity. Meanwhile, imino sugars such as NB-DGJ and DMJ, known to impact glycosylation by targeting glycosidases, might lead to shifts in glycoprotein processing dynamics, ultimately affecting enzymes like MAN1A1. It's a finely tuned balance, wherein the cell responds to external and internal cues to ensure its vital processes, including glycosylation, remain efficient and functional.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts Golgi function by blocking the transport from the ER to the Golgi, potentially leading to a compensatory increase in activities of enzymes like MAN1A1 that function in the Golgi. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is an ionophore that alters Golgi function. By perturbing the usual protein trafficking and modification routes, it can influence the activity of glycosylation-associated enzymes including MAN1A1. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
A glucose analog that acts as a competitive inhibitor for glucose in glycolysis. It can affect glycoprotein biosynthesis, potentially leading to the indirect activation of enzymes like MAN1A1 in response to altered glycoprotein processing needs. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
An ER stress inducer that can potentially enhance the glycosylation process as a cellular response to protein misfolding, indirectly leading to potential increased activity of MAN1A1. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A calcium ionophore that disturbs calcium homeostasis. Given the role of calcium in several cellular processes including protein trafficking, its modulation can potentially impact the glycosylation pathway and MAN1A1 indirectly. | ||||||
Concanavalin A | 11028-71-0 | sc-203007 sc-203007A sc-203007B | 50 mg 250 mg 1 g | $119.00 $364.00 $947.00 | 17 | |
A lectin that binds to mannose residues. By binding mannose on glycoproteins, it might potentially create a demand for mannosidase activity, potentially influencing MAN1A1. | ||||||
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $219.00 $634.00 | 5 | |
Known as a farnesyltransferase inhibitor, its interference in protein prenylation can influence various cellular pathways including glycosylation, potentially impacting MAN1A1 activity indirectly. | ||||||
Cerulenin (synthetic) | 17397-89-6 | sc-200827 sc-200827A sc-200827B | 5 mg 10 mg 50 mg | $161.00 $312.00 $1210.00 | 9 | |
An inhibitor of fatty acid synthase, influencing lipid metabolism. Given the close association of lipid rafts with protein processing in the Golgi, this might indirectly modulate MAN1A1. | ||||||
N-(n-Butyl)deoxygalactonojirimycin | 141206-42-0 | sc-221974 | 5 mg | $350.00 | 4 | |
An imino sugar that affects glycosylation. By targeting glycosidases, it might shift glycoprotein processing dynamics, indirectly modulating MAN1A1. | ||||||
Alloxan monohydrate | 2244-11-3 | sc-254940 | 10 g | $54.00 | ||
A compound known to induce oxidative stress. The ensuing cellular response might involve increased glycoprotein synthesis and processing, potentially leading to indirect activation of MAN1A1. | ||||||