MAGP-2 Inhibitors
MAGP-2 inhibitors are a class of chemical compounds designed to target and modulate the activity of Microfibril-Associated Glycoprotein 2 (MAGP-2), also known as MFAP5 (Microfibril-Associated Protein 5). MAGP-2 is a structural component of the extracellular matrix, a complex network of proteins and carbohydrates that provides structural support to various tissues in the body. It is particularly associated with microfibrils, which are essential components of elastic fibers in tissues like the skin, blood vessels, and lungs. Inhibitors of MAGP-2 are developed to interact with this glycoprotein, disrupting its structural and functional roles within the extracellular matrix.
MAGP-2 inhibitors are typically small molecules or compounds designed to bind to MAGP-2, interfering with its interactions with other extracellular matrix components, such as fibrillins and elastin. By doing so, these inhibitors may disrupt the assembly and organization of elastic fibers, affecting the mechanical properties and overall integrity of tissues rich in microfibrils. Research into MAGP-2 inhibitors can provide valuable insights into the structure and function of the extracellular matrix, shedding light on the mechanisms that underlie tissue elasticity and resilience.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Binds to DNA and inhibits RNA synthesis, which could lead to a decrease in MAGP-2 mRNA transcript levels. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
An inhibitor of RNA polymerase II, which could prevent mRNA synthesis and reduce MAGP-2 expression. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Interferes with mRNA translation in eukaryotes, potentially decreasing the production of MAGP-2 protein. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Inhibits cyclin-dependent kinases, which could affect cell cycle progression and potentially decrease MAGP-2 expression. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
A diterpene triepoxide that has been shown to inhibit transcription and may lead to reduced MAGP-2 expression. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $275.00 $474.00 $1639.00 $2497.00 $5344.00 | 4 | |
A natural product that inhibits translation and could potentially decrease the production of MAGP-2 protein. | ||||||
Homoharringtonine | 26833-87-4 | sc-202652 sc-202652A sc-202652B | 1 mg 5 mg 10 mg | $52.00 $125.00 $182.00 | 11 | |
Inhibits the initial elongation step of protein synthesis, potentially reducing MAGP-2 protein levels. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
A compound that inhibits protein synthesis, which might lead to a reduction in MAGP-2 levels. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Alkylating agent that can crosslink DNA, leading to inhibited transcription and potential reduction of MAGP-2 expression. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Inhibits DNA topoisomerase I, which can lead to reduced transcription and potentially lower MAGP-2 expression. | ||||||